Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 82001..82526 Replicon plasmid pDA34833-94
Accession NZ_CP029596
Organism Salmonella enterica strain DA34833

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag DLJ70_RS26050 Protein ID WP_001159863.1
Coordinates 82001..82306 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag DLJ70_RS26055 Protein ID WP_000813641.1
Coordinates 82308..82526 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ70_RS26010 77380..77940 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
DLJ70_RS26240 78096..78383 + 288 WP_071530243.1 hypothetical protein -
DLJ70_RS26015 78660..79145 - 486 WP_000905606.1 membrane protein -
DLJ70_RS26020 79139..79648 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
DLJ70_RS26030 79652..80365 - 714 Protein_97 EAL domain-containing protein -
DLJ70_RS26035 80374..81156 - 783 WP_000082169.1 site-specific integrase -
DLJ70_RS26040 81191..81712 - 522 WP_000198608.1 hypothetical protein -
DLJ70_RS26045 81709..81999 - 291 WP_001266176.1 hypothetical protein -
DLJ70_RS26050 82001..82306 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
DLJ70_RS26055 82308..82526 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DLJ70_RS26060 83202..83723 + 522 WP_010999942.1 hypothetical protein -
DLJ70_RS26070 84207..84503 + 297 WP_001687482.1 hypothetical protein -
DLJ70_RS26075 84997..85986 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
DLJ70_RS26080 86245..86581 - 337 Protein_106 site-specific integrase -
DLJ70_RS26085 86858..87239 - 382 Protein_107 NirD/YgiW/YdeI family stress tolerance protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94001 94001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T105974 WP_001159863.1 NZ_CP029596:c82306-82001 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T105974 NZ_CP029596:c82306-82001 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT105974 WP_000813641.1 NZ_CP029596:c82526-82308 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT105974 NZ_CP029596:c82526-82308 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References