Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1504510..1505026 Replicon chromosome
Accession NZ_CP029587
Organism Klebsiella pneumoniae strain DA33141

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag DLJ66_RS07505 Protein ID WP_002886902.1
Coordinates 1504510..1504794 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DLJ66_RS07510 Protein ID WP_002886901.1
Coordinates 1504784..1505026 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ66_RS07485 1499926..1500234 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
DLJ66_RS28255 1500319..1500492 + 174 WP_032410138.1 hypothetical protein -
DLJ66_RS07490 1500495..1501238 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
DLJ66_RS07495 1501595..1503733 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DLJ66_RS07500 1504042..1504506 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DLJ66_RS07505 1504510..1504794 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLJ66_RS07510 1504784..1505026 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DLJ66_RS07515 1505104..1507014 - 1911 WP_009486549.1 BglG family transcription antiterminator -
DLJ66_RS07520 1507037..1508191 - 1155 WP_023302389.1 lactonase family protein -
DLJ66_RS07525 1508258..1508998 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T105933 WP_002886902.1 NZ_CP029587:c1504794-1504510 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T105933 NZ_CP029587:c1504794-1504510 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT105933 WP_002886901.1 NZ_CP029587:c1505026-1504784 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT105933 NZ_CP029587:c1505026-1504784 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References