Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1419223..1420036 Replicon chromosome
Accession NZ_CP029587
Organism Klebsiella pneumoniae strain DA33141

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag DLJ66_RS07115 Protein ID WP_101516303.1
Coordinates 1419223..1419759 (-) Length 179 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag DLJ66_RS07120 Protein ID WP_023343051.1
Coordinates 1419770..1420036 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ66_RS07110 1418054..1419175 + 1122 WP_012737335.1 cupin domain-containing protein -
DLJ66_RS07115 1419223..1419759 - 537 WP_101516303.1 GNAT family N-acetyltransferase Toxin
DLJ66_RS07120 1419770..1420036 - 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
DLJ66_RS07125 1420139..1421572 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
DLJ66_RS07130 1421562..1422245 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
DLJ66_RS07135 1422418..1423803 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
DLJ66_RS07140 1423821..1424165 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19951.87 Da        Isoelectric Point: 5.7068

>T105932 WP_101516303.1 NZ_CP029587:c1419759-1419223 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSN
LLFYPTKSIEQLFTDDES

Download         Length: 537 bp

>T105932 NZ_CP029587:c1419759-1419223 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGT
TTGTTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAAC
TTACTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT105932 WP_023343051.1 NZ_CP029587:c1420036-1419770 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT105932 NZ_CP029587:c1420036-1419770 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References