Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 801599..802218 Replicon chromosome
Accession NZ_CP029587
Organism Klebsiella pneumoniae strain DA33141

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DLJ66_RS04055 Protein ID WP_002892050.1
Coordinates 802000..802218 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DLJ66_RS04050 Protein ID WP_002892066.1
Coordinates 801599..801973 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ66_RS04040 796751..797944 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DLJ66_RS04045 797967..801113 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
DLJ66_RS04050 801599..801973 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DLJ66_RS04055 802000..802218 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DLJ66_RS04060 802381..802947 + 567 WP_002892030.1 maltose O-acetyltransferase -
DLJ66_RS28115 802919..803059 - 141 WP_004147370.1 hypothetical protein -
DLJ66_RS04065 803080..803550 + 471 WP_040182126.1 YlaC family protein -
DLJ66_RS04070 803525..804976 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
DLJ66_RS04075 805077..805775 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
DLJ66_RS04080 805772..805912 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DLJ66_RS04085 805912..806175 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T105931 WP_002892050.1 NZ_CP029587:802000-802218 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T105931 NZ_CP029587:802000-802218 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCAGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT105931 WP_002892066.1 NZ_CP029587:801599-801973 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT105931 NZ_CP029587:801599-801973 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACTTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References