Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2622588..2623104 Replicon chromosome
Accession NZ_CP029582
Organism Klebsiella pneumoniae strain DA33140

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag DLJ83_RS12980 Protein ID WP_009486548.1
Coordinates 2622820..2623104 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DLJ83_RS12975 Protein ID WP_002886901.1
Coordinates 2622588..2622830 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ83_RS12960 2618616..2619356 + 741 WP_009486551.1 KDGP aldolase family protein -
DLJ83_RS12965 2619423..2620577 + 1155 WP_002886900.1 lactonase family protein -
DLJ83_RS12970 2620600..2622510 + 1911 WP_009486549.1 BglG family transcription antiterminator -
DLJ83_RS12975 2622588..2622830 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DLJ83_RS12980 2622820..2623104 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLJ83_RS12985 2623108..2623572 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DLJ83_RS12990 2623880..2626018 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DLJ83_RS12995 2626375..2627118 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DLJ83_RS28795 2627121..2627294 - 174 WP_032433782.1 hypothetical protein -
DLJ83_RS13000 2627379..2627687 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T105917 WP_009486548.1 NZ_CP029582:2622820-2623104 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T105917 NZ_CP029582:2622820-2623104 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT105917 WP_002886901.1 NZ_CP029582:2622588-2622830 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT105917 NZ_CP029582:2622588-2622830 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References