Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1999189..1999711 Replicon chromosome
Accession NZ_CP029579
Organism Escherichia coli strain DA33137

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag DLJ64_RS10385 Protein ID WP_001105433.1
Coordinates 1999189..1999479 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag DLJ64_RS10390 Protein ID WP_000212715.1
Coordinates 1999469..1999711 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ64_RS10370 1994352..1996007 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
DLJ64_RS10375 1996401..1998539 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
DLJ64_RS10380 1998724..1999188 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DLJ64_RS10385 1999189..1999479 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLJ64_RS10390 1999469..1999711 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DLJ64_RS10400 1999903..2000289 - 387 WP_001232246.1 cytochrome b562 -
DLJ64_RS10405 2000473..2001825 - 1353 WP_001162173.1 metalloprotease PmbA -
DLJ64_RS10410 2001919..2002470 + 552 WP_000166270.1 ribosome-associated protein -
DLJ64_RS10415 2002622..2003995 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T105882 WP_001105433.1 NZ_CP029579:c1999479-1999189 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T105882 NZ_CP029579:c1999479-1999189 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT105882 WP_000212715.1 NZ_CP029579:c1999711-1999469 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT105882 NZ_CP029579:c1999711-1999469 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References