Detailed information of TA system TA105881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1897630..1898444
• Replicon: chromosome
• Accession: NZ_CP029579
• Organism: Escherichia coli strain DA33137

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DLJ64_RS09790
• Protein ID: WP_001054376.1
• Coordinates: 1897630..1897887 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: DLJ64_RS09795
• Protein ID: WP_001309181.1
• Coordinates: 1897899..1898444 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ64_RS09760	1892918..1894024	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
DLJ64_RS09765	1894089..1895069	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DLJ64_RS09770	1895652..1896892	-	1241	Protein_1781	helicase YjhR	-
DLJ64_RS09780	1897008..1897253	+	246	Protein_1782	GNAT family N-acetyltransferase	-
DLJ64_RS09790	1897630..1897887	+	258	WP_001054376.1	hypothetical protein	Toxin
DLJ64_RS09795	1897899..1898444	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
DLJ64_RS09800	1898500..1899246	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
DLJ64_RS09805	1899415..1899633	+	219	Protein_1786	hypothetical protein	-
DLJ64_RS28870	1899671..1899787	+	117	Protein_1787	VOC family protein	-
DLJ64_RS09810	1900032..1901153	+	1122	WP_000010829.1	M42 family metallopeptidase	-
DLJ64_RS09815	1901150..1901428	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DLJ64_RS09820	1901440..1902753	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T105881 WP_001054376.1 NZ_CP029579:1897630-1897887 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T105881 NZ_CP029579:1897630-1897887 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT105881 WP_001309181.1 NZ_CP029579:1897899-1898444 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT105881 NZ_CP029579:1897899-1898444 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8