Detailed information of TA system TA105829

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 421486..422320
• Replicon: chromosome
• Accession: NZ_CP029576
• Organism: Escherichia coli strain DA33135

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: DLJ63_RS02275
• Protein ID: WP_001546109.1
• Coordinates: 421486..421863 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7I0L0C8
• Locus tag: DLJ63_RS02280
• Protein ID: WP_001546108.1
• Coordinates: 421940..422320 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ63_RS27595	417880..418035	-	156	WP_000729639.1	hypothetical protein	-
DLJ63_RS02250	418467..419401	-	935	Protein_412	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
DLJ63_RS02255	419394..419789	-	396	WP_000208383.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
DLJ63_RS02260	419858..420703	-	846	WP_001280441.1	DUF4942 domain-containing protein	-
DLJ63_RS02265	420788..420985	-	198	WP_000839260.1	DUF957 domain-containing protein	-
DLJ63_RS02270	421002..421489	-	488	Protein_416	hypothetical protein	-
DLJ63_RS02275	421486..421863	-	378	WP_001546109.1	TA system toxin CbtA family protein	Toxin
DLJ63_RS02280	421940..422320	-	381	WP_001546108.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DLJ63_RS02285	422370..423014	-	645	WP_000086755.1	hypothetical protein	-
DLJ63_RS02290	423033..423254	-	222	WP_000692345.1	DUF987 domain-containing protein	-
DLJ63_RS02295	423323..423799	-	477	WP_001424026.1	RadC family protein	-
DLJ63_RS02300	423815..424300	-	486	WP_000849588.1	antirestriction protein	-
DLJ63_RS02305	424355..425173	-	819	WP_001234620.1	DUF945 domain-containing protein	-
DLJ63_RS02315	425273..425506	-	234	WP_001119729.1	DUF905 family protein	-
DLJ63_RS02320	425585..426040	-	456	WP_001545736.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.00 Da
• Isoelectric Point: 8.5190

>T105829 WP_001546109.1 NZ_CP029576:c421863-421486 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T105829 NZ_CP029576:c421863-421486 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13997.78 Da
• Isoelectric Point: 5.0823

>AT105829 WP_001546108.1 NZ_CP029576:c422320-421940 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT105829 NZ_CP029576:c422320-421940 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A7I0L0C8