Detailed information of TA system TA105800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1598093..1598907
• Replicon: chromosome
• Accession: NZ_CP029574
• Organism: Escherichia coli strain DA33133

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DLJ62_RS08250
• Protein ID: WP_001054376.1
• Coordinates: 1598650..1598907 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: B7MMJ3
• Locus tag: DLJ62_RS08245
• Protein ID: WP_001338189.1
• Coordinates: 1598093..1598638 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ62_RS08220	1593784..1595097	-	1314	WP_078207780.1	galactitol-specific PTS transporter subunit IIC	-
DLJ62_RS08225	1595109..1595387	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DLJ62_RS08230	1595384..1596505	-	1122	WP_000010829.1	M42 family metallopeptidase	-
DLJ62_RS25885	1596750..1596866	-	117	Protein_1480	VOC family protein	-
DLJ62_RS08235	1596904..1597122	-	219	Protein_1481	hypothetical protein	-
DLJ62_RS08240	1597291..1598037	-	747	WP_078207781.1	class I SAM-dependent methyltransferase	-
DLJ62_RS08245	1598093..1598638	-	546	WP_001338189.1	N-acetyltransferase	Antitoxin
DLJ62_RS08250	1598650..1598907	-	258	WP_001054376.1	hypothetical protein	Toxin
DLJ62_RS08260	1599284..1599529	-	246	Protein_1485	GNAT family N-acetyltransferase	-
DLJ62_RS08270	1599660..1600885	+	1226	Protein_1486	helicase YjhR	-
DLJ62_RS08275	1601468..1602448	-	981	WP_000991455.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DLJ62_RS08280	1602513..1603619	-	1107	WP_001299704.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T105800 WP_001054376.1 NZ_CP029574:c1598907-1598650 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T105800 NZ_CP029574:c1598907-1598650 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19986.92 Da
• Isoelectric Point: 6.3277

>AT105800 WP_001338189.1 NZ_CP029574:c1598638-1598093 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT105800 NZ_CP029574:c1598638-1598093 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTTAGCAAAGAAGCCGATTTAGTGACCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: A0A0E2KXJ3