Detailed information of TA system TA105777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezA/zeta-couple_hipB
• Location: 784934..785646
• Replicon: chromosome
• Accession: NZ_CP029560
• Organism: Streptococcus sobrinus strain NIDR 6715-7

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DLJ51_RS03880
• Protein ID: WP_019769405.1
• Coordinates: 785410..785646 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DLJ51_RS03875
• Protein ID: WP_019769406.1
• Coordinates: 784934..785410 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ51_RS03855	780779..782605	+	1827	WP_109982530.1	beta-glucoside-specific PTS transporter subunit IIABC	-
DLJ51_RS03860	782616..782777	+	162	WP_109982531.1	family 1 glycosylhydrolase	-
DLJ51_RS03865	782856..783845	-	990	WP_109982532.1	IS30 family transposase	-
DLJ51_RS03870	784371..784817	+	447	WP_109982533.1	SWIM zinc finger domain-containing protein	-
DLJ51_RS03875	784934..785410	+	477	WP_019769406.1	helix-turn-helix domain-containing protein	Antitoxin
DLJ51_RS03880	785410..785646	+	237	WP_019769405.1	zeta toxin family protein	Toxin
DLJ51_RS03885	785668..785802	+	135	WP_002959687.1	zeta toxin family protein	-
DLJ51_RS03890	785840..786187	+	348	WP_109833614.1	zeta toxin family protein	-
DLJ51_RS03895	786703..788946	+	2244	WP_002959690.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	782856..783845	989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 8497.79 Da
• Isoelectric Point: 10.3607

>T105777 WP_019769405.1 NZ_CP029560:785410-785646 [Streptococcus sobrinus]
MIVAKFTEAELNRALIRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Nucleotide

• Length: 237 bp

>T105777 NZ_CP029560:785410-785646 [Streptococcus sobrinus]
ATGATAGTGGCCAAATTTACCGAAGCTGAGTTAAATAGAGCTTTAATTCGTAATAGTCGTGCTTTAATTCGAGGAAAGAA
GCCAAGTGAACATCCTACTGCTATTTTATTGGGGGGACAAAGTGGTGCAGGAAAGACAACCATTCATCGCATTAAGCAGG
AAGCTTATCAAGGAAATATCATTGTCATTGATGGTGACAGTTTTTGCCCACAGCATCCTAATTTTTCAGCGCTTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18036.83 Da
• Isoelectric Point: 4.8894

>AT105777 WP_019769406.1 NZ_CP029560:784934-785410 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANPWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Nucleotide

• Length: 477 bp

>AT105777 NZ_CP029560:784934-785410 [Streptococcus sobrinus]
ATGATTGGAGAAAATATTAAAGCCTTGCGTAAAAAAAGGGAGCTCACCCAACCAGAATTTGCTAAGATTATTGGAATTTC
ACGTAACAGTCTCAGTCGGTATGAGAATGGGACAAGTTCAGTCTCAACTGACTTACTAGATTTGATTTGCAAGAAATTCA
ATGTTTCCTACATAGATATTGTGGGAAAAGAAAAGTTATTAAGACCGATTGAAGATTATCAATTGACTTTAAAAATCGAG
TTGGCTAAAGAAAGAGGAGTCAATCTCCTAGCTCGATTGTATGCTTTTCAAGATGAGCAAGGGATTGCCGTGGATGATGA
GGCGAATCCTTGGGTGTTAATGGGTGATGATTTAGCAGATTTAGTTCACACGAAGATTTATCTTGTCAATACATTTGAGG
AATTTGAACGCTATATGGGCTATCTAGATGGTATAGAGCGCATGTTGAGTATGGCTAAACAAGGAGTAGCTGTCTAA