Detailed information of TA system TA105776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 61452..61944
• Replicon: chromosome
• Accession: NZ_CP029560
• Organism: Streptococcus sobrinus strain NIDR 6715-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DLJ51_RS00355
• Protein ID: WP_109982349.1
• Coordinates: 61678..61944 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DLJ51_RS00350
• Protein ID: WP_109982348.1
• Coordinates: 61452..61685 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ51_RS00330	56604..58151	+	1548	WP_109982346.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
DLJ51_RS00335	58355..58894	-	540	WP_002959581.1	TetR/AcrR family transcriptional regulator	-
DLJ51_RS00340	59047..59568	+	522	WP_019769995.1	HXXEE domain-containing protein	-
DLJ51_RS00345	59894..61081	+	1188	WP_109982347.1	LysM peptidoglycan-binding domain-containing protein	-
DLJ51_RS00350	61452..61685	+	234	WP_109982348.1	RelB protein	Antitoxin
DLJ51_RS00355	61678..61944	+	267	WP_109982349.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLJ51_RS00360	61999..63813	+	1815	WP_109982350.1	hypothetical protein	-
DLJ51_RS00365	63973..65232	+	1260	WP_109982351.1	phosphoribosylamine--glycine ligase	-
DLJ51_RS00370	65229..65672	+	444	WP_019783927.1	DUF523 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10135.99 Da
• Isoelectric Point: 10.5049

>T105776 WP_109982349.1 NZ_CP029560:61678-61944 [Streptococcus sobrinus]
MYKLVLSKAFIKQLSKLDKYTANSILVWLEKNIDGLDNPRQKGKALVGDLKGLWRYRVGNYRVICQIKDDQLVVVAVSGG
HRKEIYKK

Nucleotide

• Length: 267 bp

>T105776 NZ_CP029560:61678-61944 [Streptococcus sobrinus]
ATGTATAAACTGGTTTTATCGAAAGCATTCATTAAGCAATTAAGCAAGCTCGACAAATACACAGCTAACTCCATTTTAGT
TTGGCTCGAAAAGAACATTGATGGCCTAGATAATCCCAGACAAAAAGGCAAGGCCTTGGTCGGCGATTTAAAAGGGCTCT
GGCGCTACCGCGTTGGCAATTACCGAGTCATCTGCCAAATCAAAGACGACCAGCTAGTAGTTGTCGCTGTCAGCGGCGGA
CATCGCAAAGAAATCTATAAGAAGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8595.65 Da
• Isoelectric Point: 4.1948

>AT105776 WP_109982348.1 NZ_CP029560:61452-61685 [Streptococcus sobrinus]
MPVISLRLNKEEEIFFKNYAHFTGKSLSELFKNALAEEIENQLDYKLGAEGVQALEADGGQTYSIAEARDMLGLDNV

Nucleotide

• Length: 234 bp

>AT105776 NZ_CP029560:61452-61685 [Streptococcus sobrinus]
ATGCCCGTTATTTCATTACGACTGAATAAAGAAGAGGAAATCTTCTTCAAAAATTATGCACATTTCACTGGTAAAAGTTT
GTCAGAGCTTTTCAAAAATGCCTTGGCTGAAGAAATAGAAAATCAATTAGATTATAAGCTGGGTGCTGAGGGGGTACAAG
CCTTAGAAGCGGACGGCGGTCAAACCTACTCTATCGCAGAAGCGCGTGATATGCTTGGGTTAGACAATGTATAA