Detailed information of TA system TA105775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1234624..1235109
• Replicon: chromosome
• Accession: NZ_CP029559
• Organism: Streptococcus sobrinus strain NIDR 6715-15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DLJ52_RS06020
• Protein ID: WP_002962001.1
• Coordinates: 1234624..1234887 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A380JHJ3
• Locus tag: DLJ52_RS06025
• Protein ID: WP_002997994.1
• Coordinates: 1234888..1235109 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ52_RS06005	1232200..1232658	-	459	WP_109982636.1	type II toxin-antitoxin system HicB family antitoxin	-
DLJ52_RS06010	1232761..1233264	-	504	Protein_1124	DUF4411 family protein	-
DLJ52_RS06015	1233261..1234373	-	1113	WP_002997951.1	ImmA/IrrE family metallo-endopeptidase	-
DLJ52_RS06020	1234624..1234887	-	264	WP_002962001.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLJ52_RS06025	1234888..1235109	-	222	WP_002997994.1	hypothetical protein	Antitoxin
DLJ52_RS06030	1235232..1238228	-	2997	Protein_1128	type I restriction endonuclease subunit R	-
DLJ52_RS06035	1238405..1239346	+	942	WP_109982637.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-
DLJ52_RS06040	1239321..1239518	-	198	WP_002962009.1	DUF3272 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1219942..1241367	21425

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10517.09 Da
• Isoelectric Point: 10.2271

>T105775 WP_002962001.1 NZ_CP029559:c1234887-1234624 [Streptococcus sobrinus]
MYQVRYSKKAQKQIKKLDKSVQRFLFSWIDKHIDGSDNPRQFGKGLSGNHAREWRYRIGDYRLICDIEDDKLIILALEFG
HRRDIYK

Nucleotide

• Length: 264 bp

>T105775 NZ_CP029559:c1234887-1234624 [Streptococcus sobrinus]
ATGTATCAGGTTCGCTATTCCAAGAAAGCCCAGAAGCAAATTAAAAAGTTGGATAAGTCTGTTCAGAGATTCCTCTTTTC
TTGGATTGACAAGCATATAGACGGAAGTGACAACCCTAGACAGTTTGGGAAAGGCCTAAGCGGCAATCATGCCAGAGAGT
GGCGGTATCGTATCGGCGACTATCGCTTGATTTGTGATATTGAGGACGACAAGTTGATCATTCTGGCCTTAGAGTTTGGT
CATAGGAGGGACATCTATAAGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8564.57 Da
• Isoelectric Point: 4.4805

>AT105775 WP_002997994.1 NZ_CP029559:c1235109-1234888 [Streptococcus sobrinus]
MSTVTVRLNKDEEDFFKTYAQITGVSLSTLFKKSLEKAIEDEYDLKLYQEAYRAYQEDPETLSHADFKKELGF

Nucleotide

• Length: 222 bp

>AT105775 NZ_CP029559:c1235109-1234888 [Streptococcus sobrinus]
ATGAGTACAGTAACAGTCAGATTAAACAAAGATGAAGAAGACTTCTTTAAAACCTATGCTCAGATTACAGGAGTCAGTCT
TTCAACCCTCTTTAAAAAGTCGCTGGAAAAGGCCATTGAAGATGAGTATGATTTGAAACTCTATCAAGAGGCCTATCGAG
CCTACCAAGAGGATCCAGAGACTCTTTCTCACGCAGATTTTAAAAAGGAATTAGGTTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A380JHJ3