Detailed information of TA system TA105773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezA/zeta-couple_hipB
• Location: 784933..785645
• Replicon: chromosome
• Accession: NZ_CP029559
• Organism: Streptococcus sobrinus strain NIDR 6715-15

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DLJ52_RS03880
• Protein ID: WP_019769405.1
• Coordinates: 785409..785645 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DLJ52_RS03875
• Protein ID: WP_019769406.1
• Coordinates: 784933..785409 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ52_RS03855	780778..782604	+	1827	WP_109982530.1	beta-glucoside-specific PTS transporter subunit IIABC	-
DLJ52_RS03860	782615..782776	+	162	WP_109982531.1	family 1 glycosylhydrolase	-
DLJ52_RS03865	782855..783844	-	990	WP_109990561.1	IS30 family transposase	-
DLJ52_RS03870	784370..784816	+	447	WP_109982533.1	SWIM zinc finger domain-containing protein	-
DLJ52_RS03875	784933..785409	+	477	WP_019769406.1	helix-turn-helix domain-containing protein	Antitoxin
DLJ52_RS03880	785409..785645	+	237	WP_019769405.1	zeta toxin family protein	Toxin
DLJ52_RS03885	785667..785801	+	135	WP_002959687.1	zeta toxin family protein	-
DLJ52_RS03890	785839..786186	+	348	WP_109833614.1	zeta toxin family protein	-
DLJ52_RS03895	786702..788945	+	2244	WP_002959690.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	782855..783844	989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 8497.79 Da
• Isoelectric Point: 10.3607

>T105773 WP_019769405.1 NZ_CP029559:785409-785645 [Streptococcus sobrinus]
MIVAKFTEAELNRALIRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Nucleotide

• Length: 237 bp

>T105773 NZ_CP029559:785409-785645 [Streptococcus sobrinus]
ATGATAGTGGCCAAATTTACCGAAGCTGAGTTAAATAGAGCTTTAATTCGTAATAGTCGTGCTTTAATTCGAGGAAAGAA
GCCAAGTGAACATCCTACTGCTATTTTATTGGGGGGACAAAGTGGTGCAGGAAAGACAACCATTCATCGCATTAAGCAGG
AAGCTTATCAAGGAAATATCATTGTCATTGATGGTGACAGTTTTTGCCCACAGCATCCTAATTTTTCAGCGCTTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18036.83 Da
• Isoelectric Point: 4.8894

>AT105773 WP_019769406.1 NZ_CP029559:784933-785409 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANPWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Nucleotide

• Length: 477 bp

>AT105773 NZ_CP029559:784933-785409 [Streptococcus sobrinus]
ATGATTGGAGAAAATATTAAAGCCTTGCGTAAAAAAAGGGAGCTCACCCAACCAGAATTTGCTAAGATTATTGGAATTTC
ACGTAACAGTCTCAGTCGGTATGAGAATGGGACAAGTTCAGTCTCAACTGACTTACTAGATTTGATTTGCAAGAAATTCA
ATGTTTCCTACATAGATATTGTGGGAAAAGAAAAGTTATTAAGACCGATTGAAGATTATCAATTGACTTTAAAAATCGAG
TTGGCTAAAGAAAGAGGAGTCAATCTCCTAGCTCGATTGTATGCTTTTCAAGATGAGCAAGGGATTGCCGTGGATGATGA
GGCGAATCCTTGGGTGTTAATGGGTGATGATTTAGCAGATTTAGTTCACACGAAGATTTATCTTGTCAATACATTTGAGG
AATTTGAACGCTATATGGGCTATCTAGATGGTATAGAGCGCATGTTGAGTATGGCTAAACAAGGAGTAGCTGTCTAA