Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3538565..3539202 Replicon chromosome
Accession NZ_CP029553
Organism Methylobacterium terrae strain 17Sr1-28

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag DK419_RS16245 Protein ID WP_109959997.1
Coordinates 3538789..3539202 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag DK419_RS16240 Protein ID WP_109959996.1
Coordinates 3538565..3538792 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK419_RS16215 3534344..3535033 - 690 WP_109959992.1 GntR family transcriptional regulator -
DK419_RS16225 3535245..3536171 + 927 WP_109959993.1 3-hydroxyacyl-CoA dehydrogenase -
DK419_RS16230 3536183..3537112 + 930 WP_109959994.1 3-keto-5-aminohexanoate cleavage protein -
DK419_RS16235 3537399..3538418 - 1020 WP_109959995.1 SMP-30/gluconolactonase/LRE family protein -
DK419_RS16240 3538565..3538792 + 228 WP_109959996.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DK419_RS16245 3538789..3539202 + 414 WP_109959997.1 type II toxin-antitoxin system VapC family toxin Toxin
DK419_RS16250 3539224..3540294 - 1071 WP_109959998.1 malate/lactate/ureidoglycolate dehydrogenase -
DK419_RS16255 3540527..3541687 + 1161 WP_109959999.1 ABC transporter substrate-binding protein -
DK419_RS16260 3541796..3542671 + 876 WP_109960000.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14922.31 Da        Isoelectric Point: 10.1520

>T105769 WP_109959997.1 NZ_CP029553:3538789-3539202 [Methylobacterium terrae]
VKPRYLLDTNVIIALRRRRPRSVVARLTALRIGEAVMSPVTYGQLCFGAEKSVDRDSAFAVLARLVAVVPIEIAEPEETG
RRYGGLRAMLGRQGQLIGNNDVWIAAHALAANLTLVTGNVGEFSRVPGLVIEDWTAQ

Download         Length: 414 bp

>T105769 NZ_CP029553:3538789-3539202 [Methylobacterium terrae]
GTGAAGCCTCGCTACCTGCTCGATACGAACGTCATCATCGCGCTCCGGCGCAGGCGGCCACGCTCGGTCGTCGCTCGATT
GACTGCGCTCCGCATCGGCGAAGCCGTCATGTCGCCAGTGACTTACGGACAGTTGTGCTTTGGGGCGGAGAAGAGCGTGG
ATCGGGACAGCGCTTTCGCAGTCCTCGCCCGATTGGTCGCCGTCGTTCCGATCGAGATCGCTGAGCCCGAGGAAACCGGC
CGCCGCTATGGCGGACTCCGGGCCATGCTCGGACGACAAGGCCAACTGATCGGCAACAACGATGTCTGGATCGCCGCGCA
CGCTCTCGCGGCCAACCTCACGCTCGTGACCGGCAATGTCGGTGAGTTCAGCCGCGTGCCCGGTCTCGTCATCGAGGATT
GGACGGCCCAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8367.52 Da        Isoelectric Point: 4.5535

>AT105769 WP_109959996.1 NZ_CP029553:3538565-3538792 [Methylobacterium terrae]
MTVAKLFTSGGSQAVRLPREFRFDGNEVEIFRRGGEVVLRERPANLSVLLDIIDSMPADMLTDLHDGPPQEREGL

Download         Length: 228 bp

>AT105769 NZ_CP029553:3538565-3538792 [Methylobacterium terrae]
ATGACCGTCGCGAAGCTCTTCACGTCCGGAGGCAGCCAAGCCGTCAGACTGCCGCGAGAATTCCGCTTCGACGGCAACGA
GGTCGAGATTTTTCGCCGTGGCGGCGAAGTCGTCCTGCGCGAGCGCCCGGCCAATCTCTCCGTGCTCCTCGACATCATCG
ACAGCATGCCCGCCGACATGCTGACCGATTTGCACGATGGCCCGCCGCAGGAGCGCGAGGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References