Detailed information of TA system TA105767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1718340..1719110
• Replicon: chromosome
• Accession: NZ_CP029553
• Organism: Methylobacterium terrae strain 17Sr1-28

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DK419_RS07710
• Protein ID: WP_109958566.1
• Coordinates: 1718601..1719110 (+)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: DK419_RS07705
• Protein ID: WP_208642337.1
• Coordinates: 1718340..1718597 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK419_RS07685	1713538..1713804	+	267	WP_109958561.1	hypothetical protein	-
DK419_RS07690	1713962..1715911	+	1950	WP_109958562.1	acetate--CoA ligase	-
DK419_RS07695	1716207..1716515	+	309	WP_109958563.1	DUF485 domain-containing protein	-
DK419_RS07700	1716512..1718200	+	1689	WP_109958564.1	cation acetate symporter	-
DK419_RS07705	1718340..1718597	+	258	WP_208642337.1	DUF1778 domain-containing protein	Antitoxin
DK419_RS07710	1718601..1719110	+	510	WP_109958566.1	GNAT family N-acetyltransferase	Toxin
DK419_RS07715	1719142..1720425	-	1284	WP_109958567.1	DUF3422 domain-containing protein	-
DK419_RS07720	1720559..1722160	-	1602	WP_109958568.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
DK419_RS07725	1722431..1723753	+	1323	WP_109958569.1	hemolysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-75)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18024.87 Da
• Isoelectric Point: 9.2995

>T105767 WP_109958566.1 NZ_CP029553:1718601-1719110 [Methylobacterium terrae]
VALSAPEPLCASHDILAFSCGKPGLDRWLKTRALSNQEKGFTAVMVVHEARRVVGYYGLAPTAVVPNVLPRAIRTGQPPD
PVPCLLLGQLATDTGWAGRGIGKGLLHHALTRCVKAAALVGGRAVMVHAVDDEAVAFWQRWGFIATRNSEYELVRSVADI
AASFTAART

Nucleotide

• Length: 510 bp

>T105767 NZ_CP029553:1718601-1719110 [Methylobacterium terrae]
GTGGCCCTGTCCGCGCCCGAACCGCTCTGCGCGTCGCACGATATCTTGGCATTCTCGTGCGGCAAGCCGGGCCTCGACCG
CTGGCTCAAGACACGGGCGCTGTCCAACCAAGAGAAAGGCTTCACGGCCGTGATGGTCGTGCACGAGGCCCGCCGGGTGG
TCGGTTATTATGGGCTGGCGCCGACGGCCGTCGTCCCGAACGTTCTGCCTCGCGCGATCCGAACCGGGCAGCCCCCCGAT
CCGGTGCCGTGCCTGCTGCTCGGCCAGCTTGCGACAGATACCGGTTGGGCAGGGCGAGGCATCGGCAAAGGCTTACTCCA
TCACGCGCTCACGCGCTGTGTGAAGGCGGCGGCACTCGTCGGCGGACGTGCGGTCATGGTTCACGCGGTGGACGACGAGG
CCGTGGCATTCTGGCAGCGATGGGGATTCATCGCCACGCGGAACAGCGAATACGAACTCGTCCGTTCGGTCGCCGACATC
GCCGCTTCGTTCACGGCCGCTCGGACGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9489.81 Da
• Isoelectric Point: 4.4929

>AT105767 WP_208642337.1 NZ_CP029553:1718340-1718597 [Methylobacterium terrae]
MRLPEADLALIDRAASLRGRSRTDFVREAAVLTAEEVLMDQRLIRLSPEAFAEFMSIVSAPATVVPEIVEIARHRAPWEN
QDSEG

Nucleotide

• Length: 258 bp

>AT105767 NZ_CP029553:1718340-1718597 [Methylobacterium terrae]
ATGCGCCTGCCAGAGGCCGACCTAGCATTGATCGACCGTGCTGCGAGCCTACGCGGCAGATCCCGCACCGACTTCGTCCG
TGAGGCCGCCGTTCTTACGGCGGAAGAAGTGCTGATGGACCAGCGCCTGATTCGCCTCAGCCCCGAAGCGTTCGCGGAAT
TCATGAGTATCGTTTCGGCGCCCGCCACTGTGGTGCCTGAAATCGTCGAGATCGCCAGACACCGCGCGCCTTGGGAAAAC
CAAGACAGCGAGGGCTGA