Detailed information of TA system TA105766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 971655..972311
• Replicon: chromosome
• Accession: NZ_CP029553
• Organism: Methylobacterium terrae strain 17Sr1-28

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DK419_RS04355
• Protein ID: WP_109958011.1
• Coordinates: 971655..971864 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DK419_RS04360
• Protein ID: WP_109958012.1
• Coordinates: 971895..972311 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK419_RS04325	966724..967047	+	324	WP_109958005.1	hypothetical protein	-
DK419_RS04330	967051..967539	-	489	WP_109958006.1	hypothetical protein	-
DK419_RS04335	967532..967870	-	339	WP_109958007.1	rod-binding protein	-
DK419_RS04340	967966..969069	-	1104	WP_109958008.1	flagellar basal body P-ring protein FlgI	-
DK419_RS04345	969304..969720	+	417	WP_109958009.1	flagellar assembly protein FliX	-
DK419_RS04350	969881..971560	+	1680	WP_162561143.1	Tar ligand binding domain-containing protein	-
DK419_RS04355	971655..971864	+	210	WP_109958011.1	type II toxin-antitoxin system HicA family toxin	Toxin
DK419_RS04360	971895..972311	+	417	WP_109958012.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DK419_RS04365	972400..973776	+	1377	WP_109958013.1	MBOAT family protein	-
DK419_RS04370	973791..974816	+	1026	WP_167450826.1	hypothetical protein	-
DK419_RS04375	974976..975395	+	420	WP_048436190.1	RNA polymerase-binding protein DksA	-
DK419_RS04380	975946..976683	-	738	WP_109958014.1	flagellar basal body L-ring protein FlgH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (11-67)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-126)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7915.90 Da
• Isoelectric Point: 11.6976

>T105766 WP_109958011.1 NZ_CP029553:971655-971864 [Methylobacterium terrae]
MSRRSRSNRTRDVVSALRSEGWQLVRKGPGDHLQFRHPTKPGKVTVDSGEPEIPTGTLRSIYRQAGWEW

Nucleotide

• Length: 210 bp

>T105766 NZ_CP029553:971655-971864 [Methylobacterium terrae]
TTGTCCCGTCGATCGCGCAGCAACAGGACGCGGGACGTCGTCTCGGCCTTGCGGTCGGAGGGATGGCAGCTGGTACGAAA
AGGGCCGGGTGACCATCTGCAGTTCAGGCATCCGACGAAGCCCGGCAAGGTAACGGTCGATTCGGGTGAGCCCGAAATTC
CGACCGGAACGCTGCGCAGCATCTATCGCCAGGCCGGCTGGGAATGGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14751.83 Da
• Isoelectric Point: 4.6474

>AT105766 WP_109958012.1 NZ_CP029553:971895-972311 [Methylobacterium terrae]
MARLVMLIHEENGVYGASFPDFPGATTVAQDLDTLYVKAAEMLAFHVAGMVEDGEAVPPARTLREMQDDPAFREDSAGAM
IGLIDVDLPGRAVRVNISVEETILRRIDRAAALRGETRSGFLVAAAKARLSEGAAPGR

Nucleotide

• Length: 417 bp

>AT105766 NZ_CP029553:971895-972311 [Methylobacterium terrae]
ATGGCTCGCCTCGTCATGCTGATCCACGAGGAGAACGGCGTCTACGGGGCGTCCTTCCCGGATTTTCCCGGCGCCACCAC
CGTCGCGCAGGATCTCGATACGCTCTATGTGAAGGCCGCCGAGATGCTGGCGTTCCACGTCGCCGGCATGGTCGAGGACG
GAGAGGCGGTGCCGCCCGCGCGCACCCTGCGGGAGATGCAGGACGATCCGGCGTTTCGCGAGGATTCGGCCGGTGCGATG
ATCGGCCTGATCGACGTCGATCTTCCGGGCCGGGCCGTTCGGGTCAACATCTCGGTCGAGGAGACGATCCTGCGCCGGAT
CGACCGCGCCGCCGCCCTGCGGGGCGAGACCCGCTCCGGCTTCCTGGTGGCGGCCGCCAAGGCGCGTCTTTCGGAGGGCG
CGGCCCCCGGCCGTTGA