Detailed information of TA system TA105765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3463282..3463776
• Replicon: chromosome
• Accession: NZ_CP029552
• Organism: Methylobacterium sp. 17Sr1-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DK412_RS15540
• Protein ID: WP_109972666.1
• Coordinates: 3463585..3463776 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DK412_RS15535
• Protein ID: WP_109972665.1
• Coordinates: 3463282..3463554 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK412_RS15515	3458832..3459566	-	735	WP_109972661.1	aspartate/glutamate racemase family protein	-
DK412_RS15520	3459601..3460377	-	777	WP_109972662.1	ferredoxin--NADP reductase	-
DK412_RS15525	3460694..3461623	+	930	WP_109972663.1	beta-xylosidase	-
DK412_RS15530	3461630..3462463	+	834	WP_109972664.1	PIG-L family deacetylase	-
DK412_RS30640	3462468..3462629	-	162	WP_204165382.1	hypothetical protein	-
DK412_RS30250	3463148..3463270	-	123	WP_162596220.1	ribbon-helix-helix protein, CopG family	-
DK412_RS15535	3463282..3463554	-	273	WP_109972665.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DK412_RS15540	3463585..3463776	-	192	WP_109972666.1	type II toxin-antitoxin system HicA family toxin	Toxin
DK412_RS15545	3463848..3465797	-	1950	WP_109972667.1	HAMP domain-containing protein	-
DK412_RS15550	3466081..3466992	-	912	WP_109972668.1	polysaccharide deacetylase family protein	-
DK412_RS15555	3467009..3467398	-	390	WP_109972669.1	hypothetical protein	-
DK412_RS15560	3467842..3468453	+	612	WP_109972670.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-63)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-76)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 6972.11 Da
• Isoelectric Point: 12.0907

>T105765 WP_109972666.1 NZ_CP029552:c3463776-3463585 [Methylobacterium sp. 17Sr1-1]
IAQARCRRELVAQLKRDGWVSGGSEGSRHHFKHPTKPGRVTVPHPKKDLPIGTLRAVLRQAGL

Nucleotide

• Length: 192 bp

>T105765 NZ_CP029552:c3463776-3463585 [Methylobacterium sp. 17Sr1-1]
ATCGCGCAGGCTCGGTGTCGTCGAGAGCTCGTCGCGCAGCTCAAGCGGGACGGCTGGGTGTCAGGCGGGTCCGAGGGCAG
CCGCCACCACTTCAAGCACCCTACGAAGCCCGGGCGAGTGACCGTCCCGCACCCGAAGAAGGATCTGCCCATCGGCACTC
TGAGGGCCGTCCTCAGACAGGCGGGACTCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9312.41 Da
• Isoelectric Point: 4.3455

>AT105765 WP_109972665.1 NZ_CP029552:c3463554-3463282 [Methylobacterium sp. 17Sr1-1]
MRGSIAIIQPPDRSGEYAVVFPDVPGCASCGETFASAVAAGREALSLHLGSMRADGEAVPVARSYEAIVADPDWAEERQG
ATPISSPRAP

Nucleotide

• Length: 273 bp

>AT105765 NZ_CP029552:c3463554-3463282 [Methylobacterium sp. 17Sr1-1]
ATGCGGGGATCCATCGCCATCATCCAGCCGCCCGATCGCAGCGGGGAATATGCGGTCGTCTTCCCGGACGTGCCGGGCTG
TGCCAGTTGCGGAGAAACCTTCGCGTCGGCCGTCGCGGCGGGCCGGGAAGCACTCTCGCTCCATCTCGGATCCATGCGGG
CGGATGGCGAGGCTGTCCCGGTCGCGCGCAGCTACGAGGCCATCGTGGCCGATCCGGACTGGGCCGAGGAGCGGCAGGGA
GCGACGCCCATCTCATCACCCCGCGCGCCCTGA