Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(toxin)
Location 3463148..3463554 Replicon chromosome
Accession NZ_CP029552
Organism Methylobacterium sp. 17Sr1-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DK412_RS15535 Protein ID WP_109972665.1
Coordinates 3463282..3463554 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DK412_RS30250 Protein ID WP_162596220.1
Coordinates 3463148..3463270 (-) Length 41 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK412_RS15510 3458260..3458691 + 432 WP_109972660.1 OB-fold domain-containing protein -
DK412_RS15515 3458832..3459566 - 735 WP_109972661.1 aspartate/glutamate racemase family protein -
DK412_RS15520 3459601..3460377 - 777 WP_109972662.1 ferredoxin--NADP reductase -
DK412_RS15525 3460694..3461623 + 930 WP_109972663.1 beta-xylosidase -
DK412_RS15530 3461630..3462463 + 834 WP_109972664.1 PIG-L family deacetylase -
DK412_RS30640 3462468..3462629 - 162 WP_204165382.1 hypothetical protein -
DK412_RS30250 3463148..3463270 - 123 WP_162596220.1 ribbon-helix-helix protein, CopG family Antitoxin
DK412_RS15535 3463282..3463554 - 273 WP_109972665.1 type II toxin-antitoxin system HicB family antitoxin Toxin
DK412_RS15540 3463585..3463776 - 192 WP_109972666.1 type II toxin-antitoxin system HicA family toxin -
DK412_RS15545 3463848..3465797 - 1950 WP_109972667.1 HAMP domain-containing protein -
DK412_RS15550 3466081..3466992 - 912 WP_109972668.1 polysaccharide deacetylase family protein -
DK412_RS15555 3467009..3467398 - 390 WP_109972669.1 hypothetical protein -
DK412_RS15560 3467842..3468453 + 612 WP_109972670.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicB-like antitoxin of toxin-antitoxin system

(6-76)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 9312.41 Da        Isoelectric Point: 4.3455

>T105764 WP_109972665.1 NZ_CP029552:c3463554-3463282 [Methylobacterium sp. 17Sr1-1]
MRGSIAIIQPPDRSGEYAVVFPDVPGCASCGETFASAVAAGREALSLHLGSMRADGEAVPVARSYEAIVADPDWAEERQG
ATPISSPRAP

Download         Length: 273 bp

>T105764 NZ_CP029552:c3463554-3463282 [Methylobacterium sp. 17Sr1-1]
ATGCGGGGATCCATCGCCATCATCCAGCCGCCCGATCGCAGCGGGGAATATGCGGTCGTCTTCCCGGACGTGCCGGGCTG
TGCCAGTTGCGGAGAAACCTTCGCGTCGGCCGTCGCGGCGGGCCGGGAAGCACTCTCGCTCCATCTCGGATCCATGCGGG
CGGATGGCGAGGCTGTCCCGGTCGCGCGCAGCTACGAGGCCATCGTGGCCGATCCGGACTGGGCCGAGGAGCGGCAGGGA
GCGACGCCCATCTCATCACCCCGCGCGCCCTGA

Antitoxin


Download         Length: 41 a.a.        Molecular weight: 4148.73 Da        Isoelectric Point: 6.1192

>AT105764 WP_162596220.1 NZ_CP029552:c3463270-3463148 [Methylobacterium sp. 17Sr1-1]
VRVNITIDKGLLRQADEAAQARGLTRSGLIEDALAATIGA

Download         Length: 123 bp

>AT105764 NZ_CP029552:c3463270-3463148 [Methylobacterium sp. 17Sr1-1]
GTGCGAGTCAACATCACGATCGACAAGGGCTTGCTGCGTCAGGCCGACGAGGCCGCTCAGGCACGGGGCCTGACCCGCTC
GGGCCTGATCGAGGATGCGCTCGCGGCAACGATCGGGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References