Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 757696..758354 Replicon chromosome
Accession NZ_CP029552
Organism Methylobacterium sp. 17Sr1-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DK412_RS03460 Protein ID WP_109970808.1
Coordinates 757696..758100 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DK412_RS03465 Protein ID WP_109970809.1
Coordinates 758097..758354 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK412_RS03440 753669..754985 + 1317 WP_204165485.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
DK412_RS03445 755230..756159 - 930 WP_109970806.1 histone deacetylase family protein -
DK412_RS03450 756370..756984 + 615 WP_109970807.1 L,D-transpeptidase -
DK412_RS30515 757116..757430 + 315 WP_204165486.1 DUF1993 family protein -
DK412_RS30520 757330..757566 + 237 WP_204165650.1 hypothetical protein -
DK412_RS30525 757539..757664 + 126 WP_204165580.1 DUF1993 family protein -
DK412_RS03460 757696..758100 - 405 WP_109970808.1 type II toxin-antitoxin system VapC family toxin Toxin
DK412_RS03465 758097..758354 - 258 WP_109970809.1 antitoxin Antitoxin
DK412_RS03470 758615..759064 + 450 WP_109970810.1 hypothetical protein -
DK412_RS03475 759193..761196 + 2004 WP_109970811.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
DK412_RS03480 761210..761626 + 417 WP_109970812.1 gamma-glutamylcyclotransferase -
DK412_RS03485 761992..763329 + 1338 WP_109970813.1 divalent metal cation transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(16-56)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14360.50 Da        Isoelectric Point: 5.8873

>T105763 WP_109970808.1 NZ_CP029552:c758100-757696 [Methylobacterium sp. 17Sr1-1]
VSALRFLLDTNVVSDLVRNPSGSVARRISEIGSHGIATSIISVAELRYGCAKRGSTRLLQQVEAVLQGIEIVPFESPADA
EYGRLRAELEAAGRLIGPNDLLIAAQGLALGVPVVTANEAEFRRVRGLIVENWL

Download         Length: 405 bp

>T105763 NZ_CP029552:c758100-757696 [Methylobacterium sp. 17Sr1-1]
GTGAGCGCGCTGCGCTTCCTCCTCGACACCAACGTCGTGTCCGATCTCGTCCGCAACCCATCAGGCAGCGTGGCCCGGCG
GATCAGCGAAATCGGCAGCCACGGCATCGCGACGAGCATTATTTCGGTCGCCGAACTTCGATATGGGTGCGCGAAGCGTG
GATCCACGCGGCTGCTCCAGCAGGTCGAAGCCGTGCTGCAAGGAATTGAGATCGTGCCGTTCGAATCTCCGGCCGATGCC
GAGTATGGTCGCCTGCGAGCCGAGCTGGAGGCTGCCGGCCGATTGATCGGCCCCAACGATCTCCTGATCGCCGCGCAGGG
GCTCGCGCTTGGCGTCCCGGTCGTCACGGCCAACGAAGCGGAATTTCGTCGTGTTCGTGGGCTGATCGTCGAGAATTGGC
TCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9621.95 Da        Isoelectric Point: 4.2917

>AT105763 WP_109970809.1 NZ_CP029552:c758354-758097 [Methylobacterium sp. 17Sr1-1]
MANSLPSPQPREVKLFRNNRSQAVRIPAEFALPGDRVRISRDGDRLILEPVGKRDLLAILATLEPIEEDFPDFDEMLPPL
EEDPS

Download         Length: 258 bp

>AT105763 NZ_CP029552:c758354-758097 [Methylobacterium sp. 17Sr1-1]
ATGGCAAACTCGCTCCCGAGTCCGCAGCCGCGAGAGGTGAAGTTGTTTCGCAACAACCGCAGCCAGGCAGTACGCATCCC
GGCCGAGTTCGCCCTCCCCGGCGATCGGGTGCGCATCAGCCGCGACGGCGACCGCCTCATTCTGGAGCCAGTCGGCAAGA
GGGATCTGCTGGCGATCCTGGCAACGCTGGAGCCGATCGAGGAGGATTTCCCCGACTTCGATGAGATGCTGCCGCCTCTA
GAGGAAGATCCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References