Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-AbrB
Location 4417093..4417660 Replicon chromosome
Accession NZ_CP029551
Organism Methylobacterium sp. 17Sr1-43

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DK427_RS20705 Protein ID WP_109952989.1
Coordinates 4417093..4417446 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DK427_RS20710 Protein ID WP_109952992.1
Coordinates 4417433..4417660 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK427_RS20690 4413856..4415178 - 1323 WP_109952982.1 cell division protein FtsA -
DK427_RS20695 4415241..4416167 - 927 WP_109952985.1 cell division protein FtsQ/DivIB -
DK427_RS20700 4416134..4417057 - 924 WP_109952987.1 D-alanine--D-alanine ligase -
DK427_RS20705 4417093..4417446 - 354 WP_109952989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DK427_RS20710 4417433..4417660 - 228 WP_109952992.1 AbrB family transcriptional regulator Antitoxin
DK427_RS20715 4417695..4418627 - 933 WP_109952994.1 UDP-N-acetylmuramate dehydrogenase -
DK427_RS20720 4418624..4419163 - 540 WP_109952997.1 DUF559 domain-containing protein -
DK427_RS20725 4419167..4420573 - 1407 WP_109952999.1 UDP-N-acetylmuramate--L-alanine ligase -
DK427_RS20730 4420622..4421731 - 1110 WP_109953002.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-112)

Antitoxin

SpoVT-AbrB domain

(10-49)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12306.40 Da        Isoelectric Point: 10.9554

>T105762 WP_109952989.1 NZ_CP029551:c4417446-4417093 [Methylobacterium sp. 17Sr1-43]
MPTSEPTLGAGAVVIIPFPYADRLAEKRRPAVVISNASVAAAGFVWIAMITSARNAPMADDLPIADLARAGLAKPSVVRP
LKIACIDGARVLRRAGDLDSAAAERLFDRVRSLIGRS

Download         Length: 354 bp

>T105762 NZ_CP029551:c4417446-4417093 [Methylobacterium sp. 17Sr1-43]
ATGCCGACCTCTGAGCCCACGCTCGGCGCCGGGGCCGTCGTGATCATCCCGTTTCCCTACGCGGATCGGTTGGCGGAGAA
GCGGCGACCCGCTGTGGTGATCTCGAACGCATCCGTCGCGGCGGCGGGCTTCGTCTGGATCGCCATGATCACGAGCGCGC
GCAACGCGCCGATGGCGGACGACCTGCCGATCGCCGACCTGGCCCGCGCCGGGCTTGCCAAGCCCTCGGTGGTGCGCCCG
CTCAAGATCGCCTGCATCGACGGCGCGCGGGTTCTCCGACGCGCCGGCGACCTCGATTCCGCCGCCGCCGAGCGGCTGTT
CGACCGCGTCCGATCGCTGATCGGCCGCTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8328.44 Da        Isoelectric Point: 4.4367

>AT105762 WP_109952992.1 NZ_CP029551:c4417660-4417433 [Methylobacterium sp. 17Sr1-43]
MSGTAKAYSKVSVKSQTVIPAEVRERLDLRPGDRLRYLLTPRGVLIEKAPPEGEDPLVAFTEWAGPIDEEDYADL

Download         Length: 228 bp

>AT105762 NZ_CP029551:c4417660-4417433 [Methylobacterium sp. 17Sr1-43]
ATGAGCGGGACGGCGAAGGCCTACTCGAAGGTATCGGTGAAGAGCCAGACCGTGATCCCCGCGGAGGTGCGCGAGCGCCT
GGACCTCCGCCCGGGCGATCGGCTCCGCTATCTGCTCACGCCGCGCGGCGTCCTTATCGAGAAGGCGCCGCCCGAGGGCG
AGGATCCGCTGGTCGCCTTCACCGAGTGGGCCGGCCCGATCGACGAAGAAGACTATGCCGACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References