Detailed information of TA system TA105761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3788676..3789316
• Replicon: chromosome
• Accession: NZ_CP029551
• Organism: Methylobacterium sp. 17Sr1-43

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: DK427_RS17695
• Protein ID: WP_204165181.1
• Coordinates: 3788915..3789316 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: DK427_RS17690
• Protein ID: WP_109952409.1
• Coordinates: 3788676..3788903 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK427_RS17680	3786001..3786747	+	747	WP_109952407.1	precorrin-6A synthase (deacetylating)	-
DK427_RS17685	3786910..3788568	+	1659	WP_109952408.1	DEAD/DEAH box helicase	-
DK427_RS17690	3788676..3788903	+	228	WP_109952409.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DK427_RS17695	3788915..3789316	+	402	WP_204165181.1	type II toxin-antitoxin system VapC family toxin	Toxin
DK427_RS17700	3789372..3789770	-	399	WP_109952411.1	group III truncated hemoglobin	-
DK427_RS17705	3790043..3791062	+	1020	WP_109952412.1	sensor domain-containing diguanylate cyclase	-
DK427_RS17710	3791100..3791576	-	477	WP_109952413.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-122)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14428.68 Da
• Isoelectric Point: 6.4621

>T105761 WP_204165181.1 NZ_CP029551:3788915-3789316 [Methylobacterium sp. 17Sr1-43]
MLDTNICIHIRRARPLAVMRRFAKAIPGTVVTSVITYGELADGVARSQDPDEAGRRLAALARLIPVLPIEERVGALYGRL
RADLAVAGRLIGGNDLWIGTHACVADLTLVTNNVGEFERVDGLRIEDWTIDAA

Nucleotide

• Length: 402 bp

>T105761 NZ_CP029551:3788915-3789316 [Methylobacterium sp. 17Sr1-43]
ATGCTCGACACCAACATCTGCATCCACATCCGGCGAGCGCGCCCTCTCGCGGTCATGCGCCGGTTCGCGAAGGCTATACC
CGGCACCGTCGTGACGTCGGTGATCACCTACGGTGAACTCGCCGACGGTGTCGCCAGGAGCCAGGATCCCGACGAGGCCG
GCCGCCGCTTGGCCGCACTCGCGCGCCTCATTCCTGTCCTCCCGATCGAGGAGCGGGTCGGTGCGCTCTATGGCAGGCTG
CGCGCCGATCTGGCGGTGGCCGGACGCCTTATCGGCGGCAACGATCTCTGGATCGGCACGCACGCATGCGTGGCGGATCT
GACGCTGGTGACGAACAACGTCGGGGAGTTCGAACGGGTCGACGGCCTCAGGATCGAGGACTGGACGATCGACGCGGCGT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8587.72 Da
• Isoelectric Point: 4.6536

>AT105761 WP_109952409.1 NZ_CP029551:3788676-3788903 [Methylobacterium sp. 17Sr1-43]
MARTRIFQSGNSQAVRIPLEFRLKGSEVEIFRRDGELVLREVEDRGLGAAFTLLTELPPEIDHRDDLPPQEREGL

Nucleotide

• Length: 228 bp

>AT105761 NZ_CP029551:3788676-3788903 [Methylobacterium sp. 17Sr1-43]
ATGGCGCGGACCCGCATCTTCCAGTCCGGGAACAGCCAAGCTGTTCGGATCCCACTGGAATTTCGCTTGAAAGGAAGCGA
GGTCGAGATCTTTCGGCGGGATGGCGAACTCGTCCTGCGGGAAGTGGAGGATCGGGGGCTCGGCGCCGCCTTCACGCTCC
TGACCGAACTCCCACCGGAGATCGACCACCGGGACGACCTGCCGCCGCAGGAGCGCGAGGGCCTGTGA