Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4766567..4767123 Replicon chromosome
Accession NZ_CP029550
Organism Methylobacterium durans strain 17SD2-17

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DK389_RS21845 Protein ID WP_109896712.1
Coordinates 4766567..4766893 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DK389_RS21850 Protein ID WP_109892759.1
Coordinates 4766893..4767123 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK389_RS21815 4761676..4761885 + 210 WP_109892751.1 hypothetical protein -
DK389_RS21820 4762119..4762802 + 684 WP_109892753.1 DUF2147 domain-containing protein -
DK389_RS21825 4762837..4764060 - 1224 WP_109896710.1 serine hydrolase -
DK389_RS21830 4764126..4764608 - 483 WP_109892755.1 DUF427 domain-containing protein -
DK389_RS21835 4764732..4765480 + 749 Protein_4363 trehalose-phosphatase -
DK389_RS21840 4765562..4766566 + 1005 WP_109892757.1 glucokinase -
DK389_RS21845 4766567..4766893 - 327 WP_109896712.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DK389_RS21850 4766893..4767123 - 231 WP_109892759.1 antitoxin MazE family protein Antitoxin
DK389_RS21855 4767172..4768650 - 1479 WP_109892761.1 MFS transporter -
DK389_RS21860 4768816..4769058 + 243 WP_109896716.1 hypothetical protein -
DK389_RS21865 4769065..4770132 - 1068 WP_109896714.1 ABC transporter permease -
DK389_RS21870 4770192..4771114 - 923 Protein_4370 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(14-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11444.31 Da        Isoelectric Point: 8.0509

>T105760 WP_109896712.1 NZ_CP029550:c4766893-4766567 [Methylobacterium durans]
IRRGDLLTVVIPGEYGKPRPALDVQSDLFSALPSATICPLTTTLRPDAGLLRLTIEPSPSNGLRQTSQVVIDKITTIPQQ
RIGGLIGRADDHVMVAVNSALALHLGLA

Download         Length: 327 bp

>T105760 NZ_CP029550:c4766893-4766567 [Methylobacterium durans]
ATCCGCCGTGGAGACCTGCTCACCGTCGTGATCCCGGGCGAGTACGGCAAGCCGCGCCCGGCTCTCGATGTCCAATCCGA
CCTCTTCTCGGCGCTGCCTTCGGCAACGATCTGTCCGTTGACGACGACGCTGCGCCCGGACGCAGGCTTGCTTCGCCTGA
CGATTGAACCGTCGCCGTCGAACGGCTTGCGGCAGACCTCCCAAGTGGTCATCGACAAGATCACGACGATCCCGCAGCAG
CGCATCGGTGGGTTGATCGGGCGAGCCGACGATCACGTCATGGTCGCCGTGAACAGTGCTCTCGCCCTCCACCTCGGCCT
GGCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8462.55 Da        Isoelectric Point: 7.1652

>AT105760 WP_109892759.1 NZ_CP029550:c4767123-4766893 [Methylobacterium durans]
MPHHNEKPRSAASRTLTYRERMRAAGLRPVQIWVPDTRAPGFAATCRAQAEAIAAADPAGDEALRFIEDTYVWPEV

Download         Length: 231 bp

>AT105760 NZ_CP029550:c4767123-4766893 [Methylobacterium durans]
ATGCCTCACCATAACGAGAAGCCACGATCCGCAGCCTCGCGTACACTAACCTACCGGGAGCGGATGCGCGCCGCCGGCCT
GCGACCGGTTCAGATCTGGGTGCCGGACACCCGTGCACCCGGTTTCGCGGCAACGTGCCGTGCTCAGGCCGAGGCCATCG
CGGCCGCGGACCCAGCCGGGGATGAAGCCCTCCGCTTCATCGAGGACACCTACGTGTGGCCGGAGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References