Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 2449715..2450427 Replicon chromosome
Accession NZ_CP029543
Organism Mycobacterium leprae strain MRHRU-235-G

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag DIJ64_RS11550 Protein ID WP_197492508.1
Coordinates 2449715..2450239 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q9CBE3
Locus tag DIJ64_RS11555 Protein ID WP_010908719.1
Coordinates 2450257..2450427 (-) Length 57 a.a.

Genomic Context

DIJ64_RS11530DIJ64_RS11535DIJ64_RS16765DIJ64_RS11540DIJ64_RS15685DIJ64_RS11550DIJ64_RS11555DIJ64_RS11560DIJ64_RS11565DIJ64_RS11570DIJ64_RS11575
Location: 2446156..2446392 (237 bp)
Type: Others
Protein ID: WP_049769854.1
Location: 2446707..2448180 (1474 bp)
Type: Others
Protein ID: Protein_2090
Location: 2446389..2446538 (150 bp)
Type: Others
Protein ID: WP_156511849.1
Location: 2448384..2448818 (435 bp)
Type: Others
Protein ID: WP_010908717.1
Location: 2448877..2449645 (769 bp)
Type: Others
Protein ID: Protein_2092
Location: 2449715..2450239 (525 bp)
Type: Toxin
Protein ID: WP_197492508.1
Location: 2450257..2450427 (171 bp)
Type: Antitoxin
Protein ID: WP_010908719.1
Location: 2450533..2452543 (2011 bp)
Type: Others
Protein ID: Protein_2095
Location: 2452540..2453389 (850 bp)
Type: Others
Protein ID: Protein_2096
Location: 2453494..2454421 (928 bp)
Type: Others
Protein ID: Protein_2097
Location: 2454615..2455358 (744 bp)
Type: Others
Protein ID: WP_010908720.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DIJ64_RS115302446156..2446392+237WP_049769854.1hypothetical protein-
DIJ64_RS167652446389..2446538-150WP_156511849.1hypothetical protein-
DIJ64_RS115352446707..2448180+1474Protein_2090carotenoid oxygenase family protein-
DIJ64_RS115402448384..2448818-435WP_010908717.1hypothetical protein-
DIJ64_RS156852448877..2449645-769Protein_2092VOC family protein-
DIJ64_RS115502449715..2450239-525WP_197492508.1SRPBCC family proteinToxin
DIJ64_RS115552450257..2450427-171WP_010908719.1antitoxinAntitoxin
DIJ64_RS115602450533..2452543-2011Protein_2095hypothetical protein-
DIJ64_RS115652452540..2453389-850Protein_2096hypothetical protein-
DIJ64_RS115702453494..2454421-928Protein_2097MBL fold metallo-hydrolase-
DIJ64_RS115752454615..2455358-744WP_010908720.1enoyl-CoA hydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(2-50)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 18906.92 Da        Isoelectric Point: 9.9666

>T105756 WP_197492508.1 NZ_CP029543:c2450239-2449715 [Mycobacterium leprae]
MAKLTGSIDVPLPPNEAWMCASDLARFGEWLTIHRAWRSKLPEVVEKGTVIESYVEVKGMPNRIRWTVVRYKAPEAMTLN
GDGVGGVKVKLIAKVSPKDDGSVVSFDVHLGGSALFGPIGMIVAVALRTDIRESLQNFVTAFSRPEPGLIRSRALVVDQH
SRAVVEQRSASAGL

Download         Length: 525 bp

>T105756 NZ_CP029543:c2450239-2449715 [Mycobacterium leprae]
ATGGCGAAACTCACCGGATCTATCGACGTACCACTGCCACCGAATGAGGCCTGGATGTGTGCCTCCGATCTGGCCCGCTT
CGGTGAATGGCTAACGATTCACCGGGCGTGGCGCAGCAAGTTGCCTGAAGTGGTGGAGAAGGGCACGGTCATCGAGTCCT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAGATGGACGGTTGTGCGTTACAAAGCGCCTGAGGCCATGACGCTCAAC
GGCGACGGTGTTGGCGGTGTCAAGGTCAAGCTGATTGCTAAGGTTTCGCCTAAGGACGACGGCTCTGTCGTCAGCTTTGA
TGTGCATCTGGGTGGCTCCGCGCTGTTTGGACCGATAGGGATGATCGTCGCCGTTGCGCTGCGAACTGATATCCGCGAAT
CGTTACAGAACTTTGTCACGGCGTTCTCGCGACCGGAACCTGGCCTGATTAGGAGTCGGGCGCTCGTCGTTGACCAGCAT
AGTAGGGCCGTCGTCGAACAGCGGTCAGCATCGGCCGGGCTGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6182.93 Da        Isoelectric Point: 4.4883

>AT105756 WP_010908719.1 NZ_CP029543:c2450427-2450257 [Mycobacterium leprae]
VLDKAKDILVQNADKVETVLDKAGEFVDEKAKGKYTDTIYQVAEETKKAASFDTFG

Download         Length: 171 bp

>AT105756 NZ_CP029543:c2450427-2450257 [Mycobacterium leprae]
GTGCTGGACAAAGCAAAGGACATACTGGTGCAGAATGCTGACAAAGTCGAAACGGTGCTCGATAAGGCCGGCGAGTTCGT
CGACGAAAAGGCGAAAGGCAAGTACACTGACACTATCTATCAGGTAGCTGAAGAGACCAAGAAGGCCGCTAGCTTTGACA
CTTTTGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A197SER5

References