Detailed information of TA system TA105756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 2449715..2450427
• Replicon: chromosome
• Accession: NZ_CP029543
• Organism: Mycobacterium leprae strain MRHRU-235-G

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: DIJ64_RS11550
• Protein ID: WP_197492508.1
• Coordinates: 2449715..2450239 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: Q9CBE3
• Locus tag: DIJ64_RS11555
• Protein ID: WP_010908719.1
• Coordinates: 2450257..2450427 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DIJ64_RS11530	2446156..2446392	+	237	WP_049769854.1	hypothetical protein	-
DIJ64_RS16765	2446389..2446538	-	150	WP_156511849.1	hypothetical protein	-
DIJ64_RS11535	2446707..2448180	+	1474	Protein_2090	carotenoid oxygenase family protein	-
DIJ64_RS11540	2448384..2448818	-	435	WP_010908717.1	hypothetical protein	-
DIJ64_RS15685	2448877..2449645	-	769	Protein_2092	VOC family protein	-
DIJ64_RS11550	2449715..2450239	-	525	WP_197492508.1	SRPBCC family protein	Toxin
DIJ64_RS11555	2450257..2450427	-	171	WP_010908719.1	antitoxin	Antitoxin
DIJ64_RS11560	2450533..2452543	-	2011	Protein_2095	hypothetical protein	-
DIJ64_RS11565	2452540..2453389	-	850	Protein_2096	hypothetical protein	-
DIJ64_RS11570	2453494..2454421	-	928	Protein_2097	MBL fold metallo-hydrolase	-
DIJ64_RS11575	2454615..2455358	-	744	WP_010908720.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-141)

Antitoxin

• Antitoxin Rv0909/MT0933 (2-50)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 18906.92 Da
• Isoelectric Point: 9.9666

>T105756 WP_197492508.1 NZ_CP029543:c2450239-2449715 [Mycobacterium leprae]
MAKLTGSIDVPLPPNEAWMCASDLARFGEWLTIHRAWRSKLPEVVEKGTVIESYVEVKGMPNRIRWTVVRYKAPEAMTLN
GDGVGGVKVKLIAKVSPKDDGSVVSFDVHLGGSALFGPIGMIVAVALRTDIRESLQNFVTAFSRPEPGLIRSRALVVDQH
SRAVVEQRSASAGL

Nucleotide

• Length: 525 bp

>T105756 NZ_CP029543:c2450239-2449715 [Mycobacterium leprae]
ATGGCGAAACTCACCGGATCTATCGACGTACCACTGCCACCGAATGAGGCCTGGATGTGTGCCTCCGATCTGGCCCGCTT
CGGTGAATGGCTAACGATTCACCGGGCGTGGCGCAGCAAGTTGCCTGAAGTGGTGGAGAAGGGCACGGTCATCGAGTCCT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAGATGGACGGTTGTGCGTTACAAAGCGCCTGAGGCCATGACGCTCAAC
GGCGACGGTGTTGGCGGTGTCAAGGTCAAGCTGATTGCTAAGGTTTCGCCTAAGGACGACGGCTCTGTCGTCAGCTTTGA
TGTGCATCTGGGTGGCTCCGCGCTGTTTGGACCGATAGGGATGATCGTCGCCGTTGCGCTGCGAACTGATATCCGCGAAT
CGTTACAGAACTTTGTCACGGCGTTCTCGCGACCGGAACCTGGCCTGATTAGGAGTCGGGCGCTCGTCGTTGACCAGCAT
AGTAGGGCCGTCGTCGAACAGCGGTCAGCATCGGCCGGGCTGTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6182.93 Da
• Isoelectric Point: 4.4883

>AT105756 WP_010908719.1 NZ_CP029543:c2450427-2450257 [Mycobacterium leprae]
VLDKAKDILVQNADKVETVLDKAGEFVDEKAKGKYTDTIYQVAEETKKAASFDTFG

Nucleotide

• Length: 171 bp

>AT105756 NZ_CP029543:c2450427-2450257 [Mycobacterium leprae]
GTGCTGGACAAAGCAAAGGACATACTGGTGCAGAATGCTGACAAAGTCGAAACGGTGCTCGATAAGGCCGGCGAGTTCGT
CGACGAAAAGGCGAAAGGCAAGTACACTGACACTATCTATCAGGTAGCTGAAGAGACCAAGAAGGCCGCTAGCTTTGACA
CTTTTGGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A197SER5