Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 104235..104770 Replicon plasmid pHS30-1
Accession NZ_CP029493
Organism Escherichia coli strain HS30-1

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag DKQ63_RS23505 Protein ID WP_000222771.1
Coordinates 104235..104522 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag DKQ63_RS23510 Protein ID WP_001139206.1
Coordinates 104519..104770 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKQ63_RS23490 99860..103375 + 3516 WP_104769191.1 autotransporter outer membrane beta-barrel domain-containing protein -
DKQ63_RS23495 103550..103755 - 206 Protein_108 hypothetical protein -
DKQ63_RS23500 103745..103945 + 201 WP_000896262.1 DUF839 domain-containing protein -
DKQ63_RS23505 104235..104522 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DKQ63_RS23510 104519..104770 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DKQ63_RS23520 105382..109320 + 3939 WP_104730517.1 helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mph(A) / aph(6)-Id / aph(3'')-Ib / sul2 / aadA2 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / tet(A) / mcr-1.1 / floR / blaTEM-1B - 1..179444 179444
- inside IScluster/Tn aph(6)-Id / aph(3'')-Ib / sul2 / aadA2 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / tet(A) / mcr-1.1 - 31049..99275 68226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T105750 WP_000222771.1 NZ_CP029493:c104522-104235 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T105750 NZ_CP029493:c104522-104235 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT105750 WP_001139206.1 NZ_CP029493:c104770-104519 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT105750 NZ_CP029493:c104770-104519 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References