Detailed information of TA system TA105729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezA/zeta-couple_hipB
• Location: 1364886..1365598
• Replicon: chromosome
• Accession: NZ_CP029491
• Organism: Streptococcus sobrinus strain 10919

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DK182_RS06700
• Protein ID: WP_019769405.1
• Coordinates: 1364886..1365122 (-)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DK182_RS06705
• Protein ID: WP_019769406.1
• Coordinates: 1365122..1365598 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK182_RS06685	1361587..1363830	-	2244	WP_002959690.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-
DK182_RS06690	1364345..1364692	-	348	WP_109833614.1	zeta toxin family protein	-
DK182_RS06695	1364730..1364864	-	135	WP_002959687.1	zeta toxin family protein	-
DK182_RS06700	1364886..1365122	-	237	WP_019769405.1	zeta toxin family protein	Toxin
DK182_RS06705	1365122..1365598	-	477	WP_019769406.1	helix-turn-helix domain-containing protein	Antitoxin
DK182_RS06710	1365715..1366161	-	447	WP_002959681.1	SWIM zinc finger domain-containing protein	-
DK182_RS06715	1366687..1367706	+	1020	WP_204116686.1	IS30 family transposase	-
DK182_RS06720	1367785..1367946	-	162	WP_002963117.1	family 1 glycosylhydrolase	-
DK182_RS06725	1367957..1369783	-	1827	WP_019777816.1	beta-glucoside-specific PTS transporter subunit IIABC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1366687..1367706	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 8497.79 Da
• Isoelectric Point: 10.3607

>T105729 WP_019769405.1 NZ_CP029491:c1365122-1364886 [Streptococcus sobrinus]
MIVAKFTEAELNRALIRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Nucleotide

• Length: 237 bp

>T105729 NZ_CP029491:c1365122-1364886 [Streptococcus sobrinus]
ATGATAGTGGCCAAATTTACCGAAGCTGAGTTAAATAGAGCTTTAATTCGTAATAGTCGTGCTTTAATTCGAGGAAAGAA
GCCAAGTGAACATCCTACTGCTATTTTATTGGGGGGACAAAGTGGTGCAGGAAAGACAACCATTCATCGCATTAAGCAGG
AAGCTTATCAAGGAAATATCATTGTCATTGATGGTGACAGTTTTTGCCCACAGCATCCTAATTTTTCAGCGCTTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18036.83 Da
• Isoelectric Point: 4.8894

>AT105729 WP_019769406.1 NZ_CP029491:c1365598-1365122 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANPWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Nucleotide

• Length: 477 bp

>AT105729 NZ_CP029491:c1365598-1365122 [Streptococcus sobrinus]
ATGATTGGAGAAAATATTAAAGCCTTGCGTAAAAAAAGGGAGCTCACCCAACCAGAATTTGCTAAGATTATTGGAATTTC
ACGTAACAGTCTCAGTCGGTATGAGAATGGGACAAGTTCAGTCTCAACTGACTTACTAGATTTGATTTGCAAGAAATTCA
ATGTTTCCTACATAGATATTGTGGGAAAAGAAAAGTTATTAAGACCGATTGAAGATTATCAATTGACTTTAAAAATCGAG
TTGGCTAAAGAAAGAGGAGTCAATCTCCTAGCTCGATTGTATGCTTTTCAAGATGAGCAAGGGATTGCCGTGGATGATGA
GGCGAATCCTTGGGTGTTAATGGGTGATGATTTAGCAGATTTAGTTCACACGAAGATTTATCTTGTCAATACATTTGAGG
AATTTGAACGCTATATGGGCTATCTAGATGGTATAGAGCGCATGTTGAGTATGGCTAAACAAGGAGTAGCTGTCTAA