Detailed information of TA system TA105727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 923403..923888
• Replicon: chromosome
• Accession: NZ_CP029491
• Organism: Streptococcus sobrinus strain 10919

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DK182_RS04605
• Protein ID: WP_002962001.1
• Coordinates: 923625..923888 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A380JHJ3
• Locus tag: DK182_RS04600
• Protein ID: WP_002997994.1
• Coordinates: 923403..923624 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK182_RS04585	918994..919191	+	198	WP_002962009.1	DUF3272 family protein	-
DK182_RS04590	919166..920107	-	942	WP_019768703.1	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	-
DK182_RS04595	920284..923280	+	2997	WP_109833538.1	type I restriction endonuclease subunit R	-
DK182_RS04600	923403..923624	+	222	WP_002997994.1	hypothetical protein	Antitoxin
DK182_RS04605	923625..923888	+	264	WP_002962001.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DK182_RS04610	924139..925251	+	1113	WP_019777108.1	ImmA/IrrE family metallo-endopeptidase	-
DK182_RS04615	925248..925751	+	504	WP_002998175.1	DUF4411 family protein	-
DK182_RS04620	925854..926324	+	471	WP_019777109.1	type II toxin-antitoxin system HicB family antitoxin	-
DK182_RS04625	926412..926933	+	522	WP_019777110.1	hypothetical protein	-
DK182_RS04630	927079..928257	+	1179	WP_019777111.1	bacteriophage abortive infection AbiH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10517.09 Da
• Isoelectric Point: 10.2271

>T105727 WP_002962001.1 NZ_CP029491:923625-923888 [Streptococcus sobrinus]
MYQVRYSKKAQKQIKKLDKSVQRFLFSWIDKHIDGSDNPRQFGKGLSGNHAREWRYRIGDYRLICDIEDDKLIILALEFG
HRRDIYK

Nucleotide

• Length: 264 bp

>T105727 NZ_CP029491:923625-923888 [Streptococcus sobrinus]
ATGTATCAGGTTCGCTATTCCAAGAAAGCCCAGAAGCAAATTAAAAAGTTGGATAAGTCTGTTCAGAGATTCCTCTTTTC
TTGGATTGACAAGCATATAGACGGAAGCGACAACCCTAGACAGTTTGGGAAAGGCCTAAGCGGCAATCATGCCAGAGAGT
GGCGGTATCGTATCGGCGACTATCGCTTGATTTGTGATATTGAGGACGACAAGTTGATCATTCTGGCCTTAGAGTTTGGT
CATAGAAGGGATATCTATAAGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8564.57 Da
• Isoelectric Point: 4.4805

>AT105727 WP_002997994.1 NZ_CP029491:923403-923624 [Streptococcus sobrinus]
MSTVTVRLNKDEEDFFKTYAQITGVSLSTLFKKSLEKAIEDEYDLKLYQEAYRAYQEDPETLSHADFKKELGF

Nucleotide

• Length: 222 bp

>AT105727 NZ_CP029491:923403-923624 [Streptococcus sobrinus]
ATGAGTACAGTAACAGTCAGATTAAACAAAGATGAAGAAGACTTCTTTAAAACCTATGCTCAGATTACAGGAGTCAGTCT
TTCAACCCTCTTTAAAAAGTCGCTGGAAAAGGCCATTGAAGATGAGTATGATTTGAAACTCTATCAAGAGGCCTATCGAG
CCTACCAAGAGGATCCAGAGACTCTTTCTCACGCAGATTTTAAAAAGGAATTAGGTTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A380JHJ3