Detailed information of TA system TA105726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 139685..140161
• Replicon: chromosome
• Accession: NZ_CP029491
• Organism: Streptococcus sobrinus strain 10919

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DK182_RS00850
• Protein ID: WP_002959484.1
• Coordinates: 139685..139876 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2KLJ0
• Locus tag: DK182_RS00855
• Protein ID: WP_002959487.1
• Coordinates: 139880..140161 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK182_RS00825	135178..135744	+	567	WP_019771248.1	DUF1211 domain-containing protein	-
DK182_RS10490	136098..136241	-	144	WP_002959475.1	hypothetical protein	-
DK182_RS00830	136231..136644	-	414	WP_019786635.1	hypothetical protein	-
DK182_RS00835	136726..137448	+	723	WP_019786636.1	ABC transporter ATP-binding protein	-
DK182_RS00840	137453..138592	+	1140	WP_019777332.1	ABC transporter permease	-
DK182_RS00845	138816..139436	+	621	WP_002959483.1	TetR/AcrR family transcriptional regulator	-
DK182_RS10495	139614..139706	-	93	WP_197711882.1	type II toxin-antitoxin system YafQ family toxin	-
DK182_RS00850	139685..139876	-	192	WP_002959484.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DK182_RS00855	139880..140161	-	282	WP_002959487.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DK182_RS00860	140318..141184	-	867	WP_109833407.1	LysR family transcriptional regulator	-
DK182_RS00865	141295..142155	+	861	WP_019773582.1	aldo/keto reductase	-
DK182_RS00870	142255..142617	-	363	WP_019777329.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-57)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7151.47 Da
• Isoelectric Point: 10.5481

>T105726 WP_002959484.1 NZ_CP029491:c139876-139685 [Streptococcus sobrinus]
MLKLVATKQFKKDLKKIRKRGLALDKLESLIALLQAEEVLPQSYRDHALVGVFENVKSNQTVS

Nucleotide

• Length: 192 bp

>T105726 NZ_CP029491:c139876-139685 [Streptococcus sobrinus]
ATGCTCAAGCTTGTTGCTACCAAACAATTCAAAAAAGACCTAAAGAAAATTCGTAAACGAGGGCTAGCATTAGATAAACT
AGAATCTCTCATCGCTCTCCTACAAGCCGAAGAGGTGCTTCCCCAGAGTTACCGGGACCACGCCTTGGTCGGAGTTTTCG
AGAATGTCAAATCGAACCAGACTGTCTCCTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10517.83 Da
• Isoelectric Point: 4.5447

>AT105726 WP_002959487.1 NZ_CP029491:c140161-139880 [Streptococcus sobrinus]
MAKTANINLRIEPETKARAESLFNSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNHETEAAIEEARRIIAKEEKAKTY
ANLSELLDNLDED

Nucleotide

• Length: 282 bp

>AT105726 NZ_CP029491:c140161-139880 [Streptococcus sobrinus]
ATGGCAAAAACTGCAAATATTAACTTGAGAATCGAACCCGAAACCAAGGCACGCGCAGAAAGTCTCTTTAATAGTTTTGG
GATTTCCGTGACAGATGCTATCAATATTTTTCTCAACACCTCTATCATGGAGGGGGGATTTCCTTTCCAAATTAAGCAAC
CCCGCTACAATCATGAAACTGAGGCTGCCATCGAAGAGGCCCGTCGTATCATAGCTAAAGAGGAAAAAGCGAAAACCTAT
GCAAACTTGTCTGAACTCTTGGACAACTTAGATGAGGACTAG

Structures

Antitoxin

• AlphaFold DB: U2KLJ0