Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 57543..58035 Replicon chromosome
Accession NZ_CP029491
Organism Streptococcus sobrinus strain 10919

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DK182_RS00345 Protein ID WP_019777365.1
Coordinates 57769..58035 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DK182_RS00340 Protein ID WP_002959577.1
Coordinates 57543..57776 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK182_RS00320 53046..54593 + 1548 WP_109833391.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
DK182_RS00325 54797..55336 - 540 WP_109833392.1 TetR/AcrR family transcriptional regulator -
DK182_RS00330 55490..55999 + 510 WP_019777363.1 HXXEE domain-containing protein -
DK182_RS00335 56233..57414 + 1182 WP_019777364.1 LysM peptidoglycan-binding domain-containing protein -
DK182_RS00340 57543..57776 + 234 WP_002959577.1 hypothetical protein Antitoxin
DK182_RS00345 57769..58035 + 267 WP_019777365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK182_RS00350 58103..59260 - 1158 WP_019777366.1 AIPR family protein -
DK182_RS00355 59382..59657 + 276 WP_019777367.1 helix-turn-helix transcriptional regulator -
DK182_RS00360 59823..61082 + 1260 WP_109833393.1 phosphoribosylamine--glycine ligase -
DK182_RS00365 61079..61522 + 444 WP_109833394.1 DUF523 domain-containing protein -
DK182_RS00370 61645..62856 + 1212 WP_109833395.1 carboxylate--amine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10363.09 Da        Isoelectric Point: 10.6843

>T105725 WP_019777365.1 NZ_CP029491:57769-58035 [Streptococcus sobrinus]
MYRLVLSKQFIKQIKKFDKYTANSILVWLEKNIDGSDNPRQHGKALVGNLKGLWRYRIGNYRVVCRIQDEELVVVAVSGG
HRRDIYKR

Download         Length: 267 bp

>T105725 NZ_CP029491:57769-58035 [Streptococcus sobrinus]
ATGTATAGGTTAGTTCTCTCGAAGCAATTTATCAAACAAATAAAAAAATTTGATAAATATACTGCTAATTCTATTCTTGT
TTGGTTAGAAAAGAATATTGATGGTTCAGATAATCCTAGACAACATGGTAAGGCTCTTGTAGGAAATCTAAAGGGACTAT
GGCGTTATCGTATTGGAAATTATCGAGTAGTTTGTCGCATTCAAGATGAAGAATTAGTTGTTGTTGCAGTATCAGGTGGT
CATCGAAGAGATATTTATAAGAGGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8552.48 Da        Isoelectric Point: 4.0776

>AT105725 WP_002959577.1 NZ_CP029491:57543-57776 [Streptococcus sobrinus]
MAVVSLRLNQEEESFFKNYADFTGKSLSSLFKEALAQEIEDELDYKLGVEGVRAFEADGGQGYSIAEARKELGLENV

Download         Length: 234 bp

>AT105725 NZ_CP029491:57543-57776 [Streptococcus sobrinus]
ATGGCTGTTGTATCATTACGTTTAAATCAAGAGGAGGAAAGTTTCTTTAAAAATTATGCTGATTTTACAGGTAAAAGTCT
ATCTAGCTTGTTTAAAGAAGCTCTTGCTCAAGAAATTGAAGATGAGTTAGATTATAAACTGGGTGTTGAAGGTGTTAGAG
CCTTTGAAGCTGACGGTGGACAAGGATACTCTATTGCAGAAGCTCGCAAGGAATTGGGGCTAGAGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References