Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1243233..1243718 Replicon chromosome
Accession NZ_CP029490
Organism Streptococcus sobrinus strain SL1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DK181_RS06070 Protein ID WP_002962001.1
Coordinates 1243233..1243496 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DK181_RS06075 Protein ID WP_002962004.1
Coordinates 1243497..1243718 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK181_RS06045 1238627..1239217 - 591 WP_002961990.1 hypothetical protein -
DK181_RS06050 1239226..1240857 - 1632 WP_002961991.1 RNA-directed DNA polymerase -
DK181_RS06055 1240950..1242223 - 1274 Protein_1138 hypothetical protein -
DK181_RS06060 1242361..1242819 - 459 WP_002961996.1 type II toxin-antitoxin system HicB family antitoxin -
DK181_RS06065 1242852..1243034 - 183 WP_002961998.1 type II toxin-antitoxin system HicA family toxin -
DK181_RS06070 1243233..1243496 - 264 WP_002962001.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK181_RS06075 1243497..1243718 - 222 WP_002962004.1 hypothetical protein Antitoxin
DK181_RS06080 1243841..1246837 - 2997 WP_002962006.1 type I restriction endonuclease subunit R -
DK181_RS06085 1247014..1247955 + 942 WP_002962007.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
DK181_RS06090 1247930..1248127 - 198 WP_002962009.1 DUF3272 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1233405..1243742 10337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10517.09 Da        Isoelectric Point: 10.2271

>T105724 WP_002962001.1 NZ_CP029490:c1243496-1243233 [Streptococcus sobrinus]
MYQVRYSKKAQKQIKKLDKSVQRFLFSWIDKHIDGSDNPRQFGKGLSGNHAREWRYRIGDYRLICDIEDDKLIILALEFG
HRRDIYK

Download         Length: 264 bp

>T105724 NZ_CP029490:c1243496-1243233 [Streptococcus sobrinus]
ATGTATCAGGTTCGCTATTCCAAGAAAGCCCAGAAGCAAATTAAAAAGTTGGATAAGTCTGTTCAGAGATTCCTCTTTTC
TTGGATTGACAAGCATATAGACGGAAGTGACAACCCTAGACAGTTTGGGAAAGGCCTAAGCGGCAATCATGCCAGAGAGT
GGCGGTATCGTATCGGCGACTATCGCTTGATTTGTGATATTGAGGACGACAAGTTGATCATTCTGGCCTTAGAGTTTGGT
CATAGAAGGGACATCTATAAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8548.58 Da        Isoelectric Point: 4.4805

>AT105724 WP_002962004.1 NZ_CP029490:c1243718-1243497 [Streptococcus sobrinus]
MSTVTVRLNKDEEDFFKTYAQITGVSLSTLFKKSLEKAIEDEYDLKLYQEAFRAYQEDPETLSHADFKKELGF

Download         Length: 222 bp

>AT105724 NZ_CP029490:c1243718-1243497 [Streptococcus sobrinus]
ATGAGTACAGTAACAGTCAGATTAAACAAAGATGAAGAAGACTTCTTTAAAACCTATGCTCAGATTACAGGAGTCAGTCT
TTCAACCCTCTTTAAAAAGTCGCTGGAAAAGGCCATTGAAGATGAGTATGATTTGAAACTCTATCAAGAGGCCTTTCGAG
CCTACCAAGAGGATCCAGAGACTCTTTCTCACGCAGATTTTAAAAAGGAATTAGGTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References