Detailed information of TA system TA105723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1242361..1243034
• Replicon: chromosome
• Accession: NZ_CP029490
• Organism: Streptococcus sobrinus strain SL1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U2KBU0
• Locus tag: DK181_RS06065
• Protein ID: WP_002961998.1
• Coordinates: 1242852..1243034 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U2KIH2
• Locus tag: DK181_RS06060
• Protein ID: WP_002961996.1
• Coordinates: 1242361..1242819 (-)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK181_RS06040	1237408..1238613	-	1206	WP_002961989.1	restriction endonuclease subunit S	-
DK181_RS06045	1238627..1239217	-	591	WP_002961990.1	hypothetical protein	-
DK181_RS06050	1239226..1240857	-	1632	WP_002961991.1	RNA-directed DNA polymerase	-
DK181_RS06055	1240950..1242223	-	1274	Protein_1138	hypothetical protein	-
DK181_RS06060	1242361..1242819	-	459	WP_002961996.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DK181_RS06065	1242852..1243034	-	183	WP_002961998.1	type II toxin-antitoxin system HicA family toxin	Toxin
DK181_RS06070	1243233..1243496	-	264	WP_002962001.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DK181_RS06075	1243497..1243718	-	222	WP_002962004.1	hypothetical protein	-
DK181_RS06080	1243841..1246837	-	2997	WP_002962006.1	type I restriction endonuclease subunit R	-
DK181_RS06085	1247014..1247955	+	942	WP_002962007.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1233405..1243742	10337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6833.19 Da
• Isoelectric Point: 11.1577

>T105723 WP_002961998.1 NZ_CP029490:c1243034-1242852 [Streptococcus sobrinus]
MPMTQKEMVKLLTANGWTKIKGRKGSHIKLEKKGQHPIIVPHGEINKYTERAIRKQAGLL

Nucleotide

• Length: 183 bp

>T105723 NZ_CP029490:c1243034-1242852 [Streptococcus sobrinus]
ATGCCCATGACACAAAAAGAAATGGTCAAACTTTTAACTGCCAATGGTTGGACCAAAATCAAGGGTAGAAAAGGATCTCA
CATCAAATTGGAAAAGAAGGGACAGCATCCAATTATTGTCCCCCACGGTGAGATAAACAAATATACCGAAAGAGCCATCA
GAAAACAGGCCGGCCTTCTCTAG

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 16749.65 Da
• Isoelectric Point: 4.0363

>AT105723 WP_002961996.1 NZ_CP029490:c1242819-1242361 [Streptococcus sobrinus]
MLVAYPALFYYDPNEPSANPYFVTFPDIEHSATQGESPAHAILMASDYLGMALADELEQGRSLAQPSDINSLSLEANNPF
KDDEDMTLNYDPDKSFISLVSVDLANYLGSQEPIKKTLTIPRWADRLGRELGLNFSQTLTDAIADKKLGSNS

Nucleotide

• Length: 459 bp

>AT105723 NZ_CP029490:c1242819-1242361 [Streptococcus sobrinus]
ATGTTAGTCGCTTATCCTGCTCTCTTTTACTACGATCCCAATGAACCGTCAGCCAACCCTTACTTTGTCACCTTTCCAGA
TATTGAGCACTCAGCCACTCAAGGAGAATCCCCAGCCCATGCGATTCTCATGGCCAGTGACTATCTAGGAATGGCTCTGG
CAGATGAACTGGAGCAGGGCAGAAGTCTGGCTCAGCCTTCAGATATCAATAGCCTGTCCCTAGAAGCCAATAATCCCTTT
AAGGATGACGAGGACATGACCCTCAACTATGATCCTGATAAATCCTTTATCTCCCTAGTCAGCGTGGATCTTGCCAACTA
TCTAGGTAGTCAGGAACCCATCAAGAAAACCCTGACCATCCCCCGCTGGGCCGACAGACTAGGGCGTGAGCTAGGACTCA
ACTTTTCCCAGACCCTAACCGATGCCATCGCTGATAAAAAGCTAGGCAGCAATAGTTAA

Structures

Toxin

• AlphaFold DB: U2KBU0

Antitoxin

• AlphaFold DB: U2KIH2