Detailed information of TA system TA105722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 826078..826649
• Replicon: chromosome
• Accession: NZ_CP029490
• Organism: Streptococcus sobrinus strain SL1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DK181_RS04060
• Protein ID: WP_002959724.1
• Coordinates: 826078..826410 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: U2KH30
• Locus tag: DK181_RS04065
• Protein ID: WP_002959726.1
• Coordinates: 826404..826649 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK181_RS04045	821552..823165	+	1614	WP_028798515.1	alpha-glucosidase	-
DK181_RS04050	823715..824224	+	510	WP_002959718.1	DinB family protein	-
DK181_RS04055	824245..825594	+	1350	WP_028798514.1	replication-associated recombination protein A	-
DK181_RS04060	826078..826410	-	333	WP_002959724.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DK181_RS04065	826404..826649	-	246	WP_002959726.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DK181_RS04070	826800..827564	-	765	WP_019769317.1	DeoR/GlpR family DNA-binding transcription regulator	-
DK181_RS04075	827824..828252	+	429	WP_002959730.1	galactose-6-phosphate isomerase subunit LacA	-
DK181_RS04080	828280..828795	+	516	WP_002959732.1	galactose-6-phosphate isomerase subunit LacB	-
DK181_RS04085	828935..829915	+	981	WP_002959735.1	tagatose-bisphosphate aldolase	-
DK181_RS04090	830193..831026	+	834	WP_002959738.1	PRD domain-containing protein	-
DK181_RS04095	831063..831377	+	315	WP_002959739.1	PTS lactose/cellobiose transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12689.79 Da
• Isoelectric Point: 9.5954

>T105722 WP_002959724.1 NZ_CP029490:c826410-826078 [Streptococcus sobrinus]
MVEIKQGTIIKINLDPKEGHEQRGYRPYVCLSHSVVQNYSNIAIFAPISNTKRDYPFYVPLKGTKSTGKVLLDQLVTIDF
RARKYKFVEDIADSLLIELLSRVKVIFEKE

Nucleotide

• Length: 333 bp

>T105722 NZ_CP029490:c826410-826078 [Streptococcus sobrinus]
ATGGTAGAAATCAAGCAAGGAACTATAATAAAAATTAATCTAGACCCCAAGGAGGGACATGAACAAAGGGGCTATCGTCC
TTATGTCTGTTTGAGTCATAGTGTGGTGCAAAATTATTCCAATATAGCAATCTTTGCACCAATCAGTAATACCAAGCGTG
ACTACCCTTTTTATGTCCCCCTCAAAGGTACCAAATCAACTGGCAAAGTTTTACTTGACCAGCTGGTAACAATTGATTTC
AGAGCGAGAAAGTATAAATTCGTCGAAGATATTGCAGATTCTTTGCTCATTGAACTCCTATCACGTGTTAAAGTCATTTT
TGAGAAAGAGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9462.91 Da
• Isoelectric Point: 4.8146

>AT105722 WP_002959726.1 NZ_CP029490:c826649-826404 [Streptococcus sobrinus]
MPLTVNKWGNSIAIRLPKQLVQELKLQKDDILDYKISNNKLILEKKSEIPELTVEDLFKDYKGEPVDTTPFIFESKGNEQ
W

Nucleotide

• Length: 246 bp

>AT105722 NZ_CP029490:c826649-826404 [Streptococcus sobrinus]
ATGCCATTAACTGTCAATAAGTGGGGAAATAGTATTGCTATTCGTCTTCCCAAGCAATTAGTCCAAGAACTCAAACTACA
AAAAGATGATATTTTAGATTATAAAATATCAAATAATAAATTAATTTTAGAAAAAAAATCCGAAATTCCCGAATTAACTG
TTGAAGACCTTTTTAAGGACTACAAGGGAGAACCCGTAGATACGACTCCCTTTATTTTTGAGAGTAAGGGAAATGAACAA
TGGTAG

Structures

Antitoxin

• AlphaFold DB: U2KH30