Detailed information of TA system TA105721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezA/zeta-couple_hipB
• Location: 805060..805772
• Replicon: chromosome
• Accession: NZ_CP029490
• Organism: Streptococcus sobrinus strain SL1

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DK181_RS03975
• Protein ID: WP_002959684.1
• Coordinates: 805536..805772 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DK181_RS03970
• Protein ID: WP_002959682.1
• Coordinates: 805060..805536 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK181_RS03950	800905..802731	+	1827	WP_028798479.1	beta-glucoside-specific PTS transporter subunit IIABC	-
DK181_RS03955	802742..802903	+	162	WP_002963117.1	family 1 glycosylhydrolase	-
DK181_RS03960	802982..803971	-	990	WP_109821376.1	IS30 family transposase	-
DK181_RS03965	804497..804943	+	447	WP_002959681.1	SWIM zinc finger domain-containing protein	-
DK181_RS03970	805060..805536	+	477	WP_002959682.1	helix-turn-helix domain-containing protein	Antitoxin
DK181_RS03975	805536..805772	+	237	WP_002959684.1	zeta toxin family protein	Toxin
DK181_RS03980	805794..805928	+	135	WP_002959687.1	zeta toxin family protein	-
DK181_RS03985	805966..806313	+	348	Protein_728	zeta toxin family protein	-
DK181_RS03990	806828..809071	+	2244	WP_002959690.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	802982..803971	989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 8485.73 Da
• Isoelectric Point: 10.3607

>T105721 WP_002959684.1 NZ_CP029490:805536-805772 [Streptococcus sobrinus]
MIVAKFTEAELNRALTRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Nucleotide

• Length: 237 bp

>T105721 NZ_CP029490:805536-805772 [Streptococcus sobrinus]
ATGATAGTGGCCAAATTTACCGAAGCTGAGTTAAATAGAGCTTTAACTCGTAATAGTCGTGCTTTAATTCGAGGAAAGAA
GCCAAGTGAACATCCTACTGCTATTTTATTGGGGGGACAAAGTGGTGCAGGAAAGACAACCATTCATCGCATTAAGCAGG
AAGCTTATCAAGGAAATATCATTGTCATTGATGGTGACAGTTTTTGCCCACAGCATCCTAATTTTTCAGCGCTTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18052.88 Da
• Isoelectric Point: 4.8894

>AT105721 WP_002959682.1 NZ_CP029490:805060-805536 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANLWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Nucleotide

• Length: 477 bp

>AT105721 NZ_CP029490:805060-805536 [Streptococcus sobrinus]
ATGATTGGAGAAAATATTAAAGCCTTGCGTAAAAAAAGGGAGCTCACCCAACCAGAATTTGCTAAGATTATTGGAATTTC
ACGTAACAGTCTCAGTCGGTATGAGAATGGGACAAGTTCAGTCTCAACTGACTTACTAGATTTGATTTGCAAGAAATTCA
ATGTTTCCTACATAGATATTGTGGGAAAAGAAAAGTTATTAAGACCGATTGAAGATTATCAATTGACTTTAAAAATCGAG
TTGGCTAAAGAAAGAGGAGTCAATCTCCTAGCTCGATTGTATGCTTTTCAAGATGAGCAAGGGATTGCCGTGGATGATGA
GGCGAATCTTTGGGTGTTAATGGGTGATGATTTAGCAGATTTAGTTCACACGAAGATTTATCTTGTCAATACATTTGAGG
AATTTGAACGCTATATGGGCTATCTAGATGGTATAGAGCGCATGTTGAGTATGGCTAAACAAGGAGTAGCTGTCTAA