Detailed information of TA system TA105720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 147038..147514
• Replicon: chromosome
• Accession: NZ_CP029490
• Organism: Streptococcus sobrinus strain SL1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DK181_RS00875
• Protein ID: WP_002959484.1
• Coordinates: 147038..147229 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2KLJ0
• Locus tag: DK181_RS00880
• Protein ID: WP_002959487.1
• Coordinates: 147233..147514 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK181_RS10775	143434..143577	-	144	WP_002959475.1	hypothetical protein	-
DK181_RS00855	143567..143857	-	291	WP_002959477.1	hypothetical protein	-
DK181_RS00860	144079..144801	+	723	WP_002959479.1	ABC transporter ATP-binding protein	-
DK181_RS00865	144806..145945	+	1140	WP_002959481.1	ABC transporter permease	-
DK181_RS00870	146169..146789	+	621	WP_002959483.1	TetR/AcrR family transcriptional regulator	-
DK181_RS10780	146967..147059	-	93	WP_197711882.1	type II toxin-antitoxin system YafQ family toxin	-
DK181_RS00875	147038..147229	-	192	WP_002959484.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DK181_RS00880	147233..147514	-	282	WP_002959487.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DK181_RS00885	147671..148537	-	867	WP_002959489.1	LysR family transcriptional regulator	-
DK181_RS00890	148648..149508	+	861	WP_002959490.1	aldo/keto reductase	-
DK181_RS00895	149608..149970	-	363	WP_002959493.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	124667..171478	46811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-57)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7151.47 Da
• Isoelectric Point: 10.5481

>T105720 WP_002959484.1 NZ_CP029490:c147229-147038 [Streptococcus sobrinus]
MLKLVATKQFKKDLKKIRKRGLALDKLESLIALLQAEEVLPQSYRDHALVGVFENVKSNQTVS

Nucleotide

• Length: 192 bp

>T105720 NZ_CP029490:c147229-147038 [Streptococcus sobrinus]
ATGCTCAAGCTTGTTGCTACCAAACAATTCAAAAAAGACCTAAAGAAAATTCGTAAACGAGGGCTAGCATTAGATAAACT
AGAATCTCTCATCGCTCTCCTACAAGCCGAAGAGGTGCTTCCCCAGAGTTACCGGGACCACGCCTTGGTCGGAGTTTTCG
AGAATGTCAAATCGAACCAGACTGTCTCCTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10517.83 Da
• Isoelectric Point: 4.5447

>AT105720 WP_002959487.1 NZ_CP029490:c147514-147233 [Streptococcus sobrinus]
MAKTANINLRIEPETKARAESLFNSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNHETEAAIEEARRIIAKEEKAKTY
ANLSELLDNLDED

Nucleotide

• Length: 282 bp

>AT105720 NZ_CP029490:c147514-147233 [Streptococcus sobrinus]
ATGGCAAAAACTGCAAATATTAACTTGAGAATCGAACCCGAAACCAAGGCACGCGCAGAAAGTCTCTTTAATAGTTTTGG
GATTTCCGTGACAGATGCTATCAATATTTTTCTCAACACCTCTATCATGGAGGGGGGATTTCCTTTCCAAATTAAGCAAC
CCCGCTACAATCATGAAACTGAGGCTGCCATCGAAGAGGCCCGTCGTATCATAGCTAAAGAGGAAAAAGCGAAAACCTAT
GCAAACTTGTCTGAACTCTTGGACAACTTAGATGAGGACTAG

Structures

Antitoxin

• AlphaFold DB: U2KLJ0