105719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 62228..62720 Replicon chromosome
Accession NZ_CP029490
Organism Streptococcus sobrinus strain SL1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DK181_RS00365 Protein ID WP_002959575.1
Coordinates 62454..62720 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DK181_RS00360 Protein ID WP_002959577.1
Coordinates 62228..62461 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK181_RS00335 57404..57601 + 198 WP_002959584.1 hypothetical protein -
DK181_RS00340 57598..59145 + 1548 WP_002959583.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
DK181_RS00345 59349..59888 - 540 WP_002959581.1 TetR/AcrR family transcriptional regulator -
DK181_RS00350 60041..60562 + 522 WP_002959580.1 HXXEE domain-containing protein -
DK181_RS00355 60888..62099 + 1212 WP_028798497.1 LysM peptidoglycan-binding domain-containing protein -
DK181_RS00360 62228..62461 + 234 WP_002959577.1 hypothetical protein Antitoxin
DK181_RS00365 62454..62720 + 267 WP_002959575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK181_RS00370 62788..63945 - 1158 WP_019776570.1 AIPR family protein -
DK181_RS00375 64067..64342 + 276 WP_002959570.1 helix-turn-helix domain-containing protein -
DK181_RS00380 64508..65767 + 1260 WP_002959569.1 phosphoribosylamine--glycine ligase -
DK181_RS00385 65764..66207 + 444 WP_002959567.1 DUF523 domain-containing protein -
DK181_RS00390 66331..67542 + 1212 WP_002959564.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10419.20 Da        Isoelectric Point: 10.8196

>T105719 WP_002959575.1 NZ_CP029490:62454-62720 [Streptococcus sobrinus]
MYRLVLSKRFIKQIKKFDKYTVNSILVWLEKNIDGSDNPRQHGKALVGNLKGLWRYRIGNYRVVCRIQDEELVVVAVSGG
HRRDIYKR

Download         Length: 267 bp

>T105719 NZ_CP029490:62454-62720 [Streptococcus sobrinus]
ATGTATAGGTTAGTTCTCTCGAAGCGATTTATCAAACAAATAAAAAAATTTGATAAATATACTGTTAATTCTATTCTTGT
TTGGTTAGAAAAGAATATTGATGGTTCAGATAATCCTAGACAACATGGTAAGGCTCTTGTAGGAAATCTAAAGGGACTAT
GGCGTTATCGTATTGGAAATTATCGAGTAGTTTGTCGCATTCAAGATGAAGAATTAGTTGTTGTTGCAGTATCAGGTGGT
CATCGAAGAGATATTTATAAGAGGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8552.48 Da        Isoelectric Point: 4.0776

>AT105719 WP_002959577.1 NZ_CP029490:62228-62461 [Streptococcus sobrinus]
MAVVSLRLNQEEESFFKNYADFTGKSLSSLFKEALAQEIEDELDYKLGVEGVRAFEADGGQGYSIAEARKELGLENV

Download         Length: 234 bp

>AT105719 NZ_CP029490:62228-62461 [Streptococcus sobrinus]
ATGGCTGTTGTATCATTACGTTTAAATCAAGAGGAGGAAAGTTTCTTTAAAAATTATGCTGATTTTACAGGTAAAAGTCT
ATCTAGCTTGTTTAAAGAAGCTCTTGCTCAAGAAATTGAAGATGAGTTAGATTATAAACTGGGTGTTGAAGGTGTTAGAG
CCTTTGAAGCTGACGGTGGACAAGGATACTCTATTGCAGAAGCTCGCAAGGAATTGGGGCTAGAGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References