Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3721070..3721611 Replicon chromosome
Accession NZ_CP029488
Organism Salinisphaera sp. LB1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SALB1_RS16635 Protein ID WP_109994865.1
Coordinates 3721070..3721396 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SALB1_RS16640 Protein ID WP_109995510.1
Coordinates 3721393..3721611 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SALB1_RS16600 3716295..3716990 - 696 WP_109994859.1 SMC-Scp complex subunit ScpB -
SALB1_RS16605 3716987..3717802 - 816 WP_179950681.1 segregation/condensation protein A -
SALB1_RS16610 3717818..3718834 - 1017 WP_109994861.1 tryptophan--tRNA ligase -
SALB1_RS16615 3718913..3719551 - 639 WP_109995509.1 threonylcarbamoyl-AMP synthase -
SALB1_RS16620 3719653..3719952 + 300 WP_109994862.1 hypothetical protein -
SALB1_RS16625 3719962..3720228 + 267 WP_109994863.1 BolA family transcriptional regulator -
SALB1_RS19075 3720304..3720474 + 171 WP_120247048.1 TonB-dependent receptor -
SALB1_RS16630 3720494..3720895 - 402 WP_145961356.1 hypothetical protein -
SALB1_RS16635 3721070..3721396 - 327 WP_109994865.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SALB1_RS16640 3721393..3721611 - 219 WP_109995510.1 antitoxin MazE family protein Antitoxin
SALB1_RS16645 3721752..3723857 - 2106 WP_109994866.1 NAD-dependent DNA ligase LigA -
SALB1_RS16650 3723857..3724804 - 948 WP_109994867.1 cell division protein ZipA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(5-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11746.68 Da        Isoelectric Point: 9.9410

>T105717 WP_109994865.1 NZ_CP029488:c3721396-3721070 [Salinisphaera sp. LB1]
MTRGDFVTIAIQGDYGKPRPAVIIQADQFHEHATVTVLPVTSTRVAAPLFRIAIQPSDANGLQKASQVMVDKAITVKRSR
VGQVFGRIDPDSMLEVERCLAVFLGIAK

Download         Length: 327 bp

>T105717 NZ_CP029488:c3721396-3721070 [Salinisphaera sp. LB1]
ATGACGCGGGGCGACTTTGTGACTATTGCCATTCAAGGCGATTATGGCAAACCGAGACCCGCAGTCATCATTCAGGCCGA
TCAATTCCATGAGCACGCTACAGTGACCGTATTACCGGTAACAAGCACTCGAGTAGCCGCGCCCTTATTTCGTATTGCCA
TTCAACCGAGCGACGCCAATGGCTTGCAGAAAGCTTCGCAGGTGATGGTAGATAAAGCCATAACCGTTAAACGTTCCAGG
GTAGGCCAAGTGTTCGGACGTATTGATCCAGATTCAATGCTGGAGGTTGAACGGTGCCTGGCTGTGTTTCTAGGCATCGC
CAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8225.27 Da        Isoelectric Point: 5.8017

>AT105717 WP_109995510.1 NZ_CP029488:c3721611-3721393 [Salinisphaera sp. LB1]
MPDVNSRVRKHRDALRMAGLRPVQIWVPDTRRAGFLEECRRQSRLAAAADRADIDTQAFMDDALADIDGWTE

Download         Length: 219 bp

>AT105717 NZ_CP029488:c3721611-3721393 [Salinisphaera sp. LB1]
ATGCCTGACGTCAATTCAAGAGTTCGAAAGCATCGTGATGCGTTGCGCATGGCAGGACTGCGGCCGGTGCAAATCTGGGT
GCCTGATACGCGCCGGGCCGGTTTTTTGGAAGAATGCCGCCGCCAGTCACGGCTCGCAGCTGCAGCAGACCGGGCCGACA
TCGATACGCAGGCGTTCATGGATGATGCGCTCGCTGATATCGACGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References