Detailed information of TA system TA105716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2301332..2301980
• Replicon: chromosome
• Accession: NZ_CP029488
• Organism: Salinisphaera sp. LB1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: SALB1_RS10410
• Protein ID: WP_109993806.1
• Coordinates: 2301332..2301646 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SALB1_RS10415
• Protein ID: WP_109993807.1
• Coordinates: 2301636..2301980 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SALB1_RS10400	2297251..2297571	+	321	WP_109993804.1	hypothetical protein	-
SALB1_RS10405	2297628..2301173	+	3546	WP_109993805.1	SWIM zinc finger family protein	-
SALB1_RS10410	2301332..2301646	+	315	WP_109993806.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SALB1_RS10415	2301636..2301980	+	345	WP_109993807.1	putative addiction module antidote protein	Antitoxin
SALB1_RS10420	2302060..2303565	+	1506	WP_109993808.1	TIGR02677 family protein	-
SALB1_RS10425	2303698..2303907	+	210	WP_145961299.1	hypothetical protein	-
SALB1_RS10430	2304084..2305289	+	1206	WP_109993810.1	TIGR02678 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-94)

Antitoxin

• Uncharacterized protein HI1420 (12-95)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11755.34 Da
• Isoelectric Point: 9.4287

>T105716 WP_109993806.1 NZ_CP029488:2301332-2301646 [Salinisphaera sp. LB1]
VDIKQTLEFAHWLDSLKDKRAQLRIDIRIRRLADGNPGEHRDLKGGVSELKIREGKAYRVYYTERGGELVILLCGGDKSS
KTKQQADIAKAQRLAANLGETDDY

Nucleotide

• Length: 315 bp

>T105716 NZ_CP029488:2301332-2301646 [Salinisphaera sp. LB1]
GTGGATATCAAGCAGACACTCGAGTTTGCCCACTGGCTCGATAGCCTGAAGGACAAGCGGGCCCAGTTGCGCATTGATAT
CCGCATCCGCCGGTTGGCTGACGGCAACCCGGGCGAGCACCGTGATCTGAAAGGCGGCGTCAGCGAACTGAAGATTCGCG
AAGGTAAGGCCTACCGGGTGTATTACACCGAGCGCGGTGGCGAACTGGTGATTCTGCTATGTGGGGGCGACAAATCCAGC
AAAACGAAACAGCAGGCCGATATCGCGAAAGCGCAACGGCTCGCTGCGAATCTGGGTGAAACCGATGATTACTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12731.33 Da
• Isoelectric Point: 4.7132

>AT105716 WP_109993807.1 NZ_CP029488:2301636-2301980 [Salinisphaera sp. LB1]
MITETIPFDPSRHLDTAADMAMYLDMVLEYNDGRLLSQALGDIARSRGMSDLARQTGLSRESLYRALSDQGNPNLATLMK
IFNALGLRLSVKEREEPETQTTTSDIAEHEASKR

Nucleotide

• Length: 345 bp

>AT105716 NZ_CP029488:2301636-2301980 [Salinisphaera sp. LB1]
ATGATTACTGAGACCATTCCATTCGACCCGTCCCGACATCTCGATACAGCAGCCGACATGGCGATGTATCTGGATATGGT
CCTTGAATACAACGACGGCCGTCTGCTTTCCCAGGCGTTGGGCGACATCGCGCGGTCGCGGGGCATGAGCGATCTGGCGC
GCCAGACCGGCTTGTCCCGCGAGTCGCTATATCGCGCCTTGTCGGACCAGGGCAATCCGAATCTGGCGACGCTCATGAAG
ATATTTAACGCCCTTGGCCTGCGCTTGTCCGTCAAGGAGCGTGAGGAACCCGAGACGCAGACTACGACTTCAGATATCGC
GGAGCACGAGGCGAGTAAACGTTGA