Detailed information of TA system TA105714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 3666663..3667152
• Replicon: chromosome
• Accession: NZ_CP029487
• Organism: Eubacterium maltosivorans strain YI

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0U3EN50
• Locus tag: CPZ25_RS16960
• Protein ID: WP_058695706.1
• Coordinates: 3666877..3667152 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CPZ25_RS16955
• Protein ID: WP_096920100.1
• Coordinates: 3666663..3666884 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPZ25_RS16935	3662259..3662753	+	495	WP_096920104.1	hypothetical protein	-
CPZ25_RS16940	3662785..3664278	-	1494	WP_096920103.1	glycerol kinase GlpK	-
CPZ25_RS16945	3664290..3665825	-	1536	WP_096920102.1	amidohydrolase	-
CPZ25_RS16950	3665830..3666405	-	576	WP_167495262.1	glycerol-3-phosphate responsive antiterminator	-
CPZ25_RS16955	3666663..3666884	+	222	WP_096920100.1	ribbon-helix-helix protein, CopG family	Antitoxin
CPZ25_RS16960	3666877..3667152	+	276	WP_058695706.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPZ25_RS16965	3667274..3670645	+	3372	WP_096920099.1	exodeoxyribonuclease V subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-87)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10571.34 Da
• Isoelectric Point: 10.2341

>T105714 WP_058695706.1 NZ_CP029487:3666877-3667152 [Eubacterium maltosivorans]
MAEKYHVVLTEKAKKSLKKLDRHTALLITGWLRKNLEGCANPYQYGKSLSANRSGQWRYRIGDYRLVCEISEQTITILVL
NVGHRKEICKH

Nucleotide

• Length: 276 bp

>T105714 NZ_CP029487:3666877-3667152 [Eubacterium maltosivorans]
TTGGCTGAGAAATATCATGTCGTTTTAACTGAAAAGGCGAAAAAAAGCCTGAAAAAGCTTGACAGACATACTGCGCTTTT
AATTACAGGCTGGTTAAGAAAAAATCTTGAAGGCTGCGCCAACCCCTATCAGTACGGCAAGAGTCTCAGCGCGAACCGAA
GCGGGCAGTGGCGTTACCGTATCGGCGATTACCGCCTGGTCTGCGAGATTTCAGAGCAGACCATCACCATTCTTGTTTTA
AATGTGGGACACCGGAAAGAAATTTGTAAGCATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8563.68 Da
• Isoelectric Point: 4.1285

>AT105714 WP_096920100.1 NZ_CP029487:3666663-3666884 [Eubacterium maltosivorans]
MAVSVRLNKEDEALIRNYAQMKNLSVSEAIRQAVMEKIEDEFDLKVYYEAMAEYKENPVTYTLDEVERELEIG

Nucleotide

• Length: 222 bp

>AT105714 NZ_CP029487:3666663-3666884 [Eubacterium maltosivorans]
ATGGCAGTATCCGTAAGATTAAATAAAGAGGATGAGGCGTTGATTCGAAACTATGCGCAGATGAAGAACCTGTCGGTTTC
CGAGGCCATTCGTCAGGCGGTCATGGAAAAGATTGAGGACGAGTTTGATTTAAAGGTTTATTATGAGGCCATGGCGGAAT
ATAAAGAAAATCCGGTGACCTACACCTTGGACGAAGTGGAAAGAGAGCTGGAAATTGGCTGA

Structures

Toxin

• AlphaFold DB: A0A0U3EN50