Detailed information of TA system TA105707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 919822..920518
• Replicon: chromosome
• Accession: NZ_CP029479
• Organism: Phenylobacterium parvum strain HYN0004

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HYN04_RS04380
• Protein ID: WP_110449628.1
• Coordinates: 920102..920518 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HYN04_RS04375
• Protein ID: WP_110449627.1
• Coordinates: 919822..920088 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYN04_RS04360	914826..915557	+	732	WP_110449624.1	DUF4163 domain-containing protein	-
HYN04_RS04365	915989..918139	-	2151	WP_110449625.1	methylmalonyl-CoA mutase	-
HYN04_RS04370	918139..919560	-	1422	WP_110449626.1	methylmalonyl-CoA mutase	-
HYN04_RS04375	919822..920088	+	267	WP_110449627.1	plasmid stabilization protein	Antitoxin
HYN04_RS04380	920102..920518	+	417	WP_110449628.1	PIN domain-containing protein	Toxin
HYN04_RS04385	920719..921849	-	1131	WP_110449629.1	serine hydrolase	-
HYN04_RS04390	921867..923003	-	1137	WP_110449630.1	serine hydrolase	-
HYN04_RS04395	923818..924819	+	1002	WP_110449631.1	nitronate monooxygenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14389.49 Da
• Isoelectric Point: 4.8232

>T105707 WP_110449628.1 NZ_CP029479:920102-920518 [Phenylobacterium parvum]
MILLDTNVISEAIKPEPHPSVRAWLDAQVAETLFLSSVTVAELLFGIGVLAEGRRKTLLAARVDGLLDVFAGRVLPFDAA
AARRYADLAVRVRTAGKGSPTPDGYIAAIAAANGFAVASGDTSAFNAAGLAVINPWEE

Nucleotide

• Length: 417 bp

>T105707 NZ_CP029479:920102-920518 [Phenylobacterium parvum]
ATGATCCTCCTCGACACCAATGTCATCTCCGAGGCGATCAAGCCGGAGCCTCACCCGTCGGTGCGCGCCTGGCTTGACGC
CCAGGTGGCGGAGACCCTGTTCCTGTCCAGCGTCACCGTCGCCGAGCTCCTGTTCGGCATCGGCGTCCTGGCGGAGGGCC
GGCGGAAGACCCTGCTCGCGGCCCGGGTCGATGGCCTGCTGGACGTCTTCGCGGGCCGGGTCCTGCCCTTCGATGCGGCG
GCGGCCCGGCGTTACGCCGACCTGGCGGTCCGGGTCCGCACGGCGGGGAAGGGATCCCCGACCCCCGACGGCTACATCGC
CGCGATCGCCGCGGCGAACGGGTTCGCCGTGGCTTCCGGGGACACCAGCGCGTTCAACGCCGCAGGCCTGGCCGTGATCA
ACCCCTGGGAGGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9800.21 Da
• Isoelectric Point: 5.1992

>AT105707 WP_110449627.1 NZ_CP029479:919822-920088 [Phenylobacterium parvum]
MPAVTIRNLPEEVHRALKVRAALHDRSTEAEMRAILEAAVRPDGRLRLGTALSEASRELGLTNADIEALESSLELVRDRR
PAEPMIFE

Nucleotide

• Length: 267 bp

>AT105707 NZ_CP029479:919822-920088 [Phenylobacterium parvum]
ATGCCGGCAGTCACCATCCGCAACCTTCCCGAGGAAGTGCATCGCGCCCTGAAGGTCCGGGCGGCCCTGCATGATCGCAG
CACCGAGGCCGAGATGCGCGCCATCCTTGAGGCCGCCGTGCGGCCCGACGGCCGACTGCGGCTGGGCACGGCCCTGTCGG
AAGCCAGCCGGGAACTGGGCCTCACCAACGCCGACATCGAGGCCCTCGAGTCTTCCCTCGAACTGGTCCGTGACCGGCGG
CCTGCCGAGCCCATGATCTTTGAATGA