Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1812277..1812854 Replicon chromosome
Accession NZ_CP029477
Organism Lactobacillus kullabergensis strain ESL0186

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DKL58_RS08600 Protein ID WP_109586827.1
Coordinates 1812522..1812854 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DKL58_RS08595 Protein ID WP_109586826.1
Coordinates 1812277..1812528 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKL58_RS08570 1808536..1808814 + 279 WP_109586822.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
DKL58_RS08575 1808802..1809146 + 345 WP_109586823.1 type II toxin-antitoxin system PemK/MazF family toxin -
DKL58_RS08580 1809258..1809581 - 324 WP_109586824.1 hypothetical protein -
DKL58_RS08585 1809817..1810734 - 918 WP_109586825.1 cytochrome C5 -
DKL58_RS08590 1810884..1812122 + 1239 WP_046332720.1 MFS transporter -
DKL58_RS08595 1812277..1812528 + 252 WP_109586826.1 hypothetical protein Antitoxin
DKL58_RS08600 1812522..1812854 + 333 WP_109586827.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DKL58_RS08610 1813425..1814669 - 1245 WP_109586828.1 MFS transporter -
DKL58_RS08615 1814776..1815639 + 864 WP_109586829.1 hypothetical protein -
DKL58_RS08620 1815835..1816470 + 636 WP_109586830.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12753.86 Da        Isoelectric Point: 9.4243

>T105705 WP_109586827.1 NZ_CP029477:1812522-1812854 [Lactobacillus kullabergensis]
MVIKQGSILLMDLSPKQGHEQSGKRPYLYLSYKGVEKYAHIAVFAPISTTKRRYPLYQELPAASQTKGVVMLDQLVTIDY
HNQSFQYLEQLPDDYMEKILKIVKVVFQKD

Download         Length: 333 bp

>T105705 NZ_CP029477:1812522-1812854 [Lactobacillus kullabergensis]
ATGGTAATTAAGCAAGGATCTATTCTATTAATGGATTTAAGTCCTAAACAGGGGCATGAACAATCTGGCAAACGACCTTA
TTTATATTTAAGCTATAAAGGGGTTGAAAAATACGCTCATATTGCTGTGTTTGCTCCTATATCAACTACTAAAAGACGCT
ACCCCTTATATCAAGAATTACCTGCTGCATCTCAAACAAAAGGCGTAGTCATGCTAGATCAGCTAGTTACAATCGATTAT
CATAATCAATCATTTCAATATTTAGAGCAACTACCTGATGACTATATGGAAAAGATACTCAAAATTGTAAAAGTAGTTTT
TCAGAAAGATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9562.75 Da        Isoelectric Point: 4.3654

>AT105705 WP_109586826.1 NZ_CP029477:1812277-1812528 [Lactobacillus kullabergensis]
MIRATISKWGNSKGIRLNQAVLQALNATIGDQLNFIIEDNKVIMSKQDDTPDLTFEELFKDYSGEEFDTEIKLPDERKGN
EKW

Download         Length: 252 bp

>AT105705 NZ_CP029477:1812277-1812528 [Lactobacillus kullabergensis]
ATGATTCGGGCTACTATATCTAAATGGGGTAATTCTAAAGGCATCCGATTAAACCAAGCAGTCTTGCAAGCATTAAACGC
TACTATAGGAGATCAGTTAAACTTTATAATTGAGGACAACAAAGTAATAATGTCAAAGCAAGATGATACACCTGATTTAA
CTTTTGAAGAACTTTTTAAAGATTATTCAGGTGAAGAATTTGATACCGAAATTAAGTTACCAGATGAGAGAAAAGGAAAT
GAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References