Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1543430..1543907 Replicon chromosome
Accession NZ_CP029474
Organism Staphylococcus aureus strain USA 100 isolate 30-47

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DKK89_RS07850 Protein ID WP_000052076.1
Coordinates 1543430..1543618 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DKK89_RS07855 Protein ID WP_001059690.1
Coordinates 1543647..1543907 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKK89_RS07820 1539424..1539945 + 522 WP_000824482.1 hypothetical protein -
DKK89_RS07825 1540286..1540972 + 687 WP_000141557.1 thermonuclease family protein -
DKK89_RS07830 1541329..1541529 + 201 WP_001059082.1 cold-shock protein -
DKK89_RS07835 1542021..1542239 - 219 WP_000005886.1 hypothetical protein -
DKK89_RS07840 1542316..1542585 - 270 WP_001004398.1 hypothetical protein -
DKK89_RS07845 1542673..1543242 - 570 WP_001106658.1 hypothetical protein -
DKK89_RS07850 1543430..1543618 - 189 WP_000052076.1 hypothetical protein Toxin
DKK89_RS07855 1543647..1543907 - 261 WP_001059690.1 hypothetical protein Antitoxin
DKK89_RS07860 1544248..1544451 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DKK89_RS07865 1544448..1544684 - 237 WP_000349581.1 hypothetical protein -
DKK89_RS07870 1544909..1545490 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
DKK89_RS07875 1545563..1546180 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
DKK89_RS07880 1546335..1546829 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
DKK89_RS07890 1547228..1547650 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DKK89_RS07895 1547798..1548514 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T105701 WP_000052076.1 NZ_CP029474:c1543618-1543430 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T105701 NZ_CP029474:c1543618-1543430 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT105701 WP_001059690.1 NZ_CP029474:c1543907-1543647 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT105701 NZ_CP029474:c1543907-1543647 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References