105689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1408523..1409439 Replicon chromosome
Accession NZ_CP029465
Organism Bacillus inaquosorum strain KCTC 13429

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2M8T4L2
Locus tag DKG76_RS07225 Protein ID WP_003239094.1
Coordinates 1408693..1409439 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4NV07
Locus tag DKG76_RS07220 Protein ID WP_003239095.1
Coordinates 1408523..1408693 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKG76_RS07180 1403767..1404345 + 579 WP_003239106.1 YmfQ family protein -
DKG76_RS07185 1404342..1404614 + 273 WP_003239104.1 hypothetical protein -
DKG76_RS07190 1404617..1406107 + 1491 WP_003239103.1 hypothetical protein -
DKG76_RS07195 1406120..1406560 + 441 WP_003239102.1 hypothetical protein -
DKG76_RS07200 1406550..1406741 + 192 WP_032732119.1 XkdX family protein -
DKG76_RS07205 1406813..1407082 + 270 WP_032732173.1 hemolysin XhlA family protein -
DKG76_RS07210 1407095..1407358 + 264 WP_003239099.1 phage holin -
DKG76_RS07215 1407371..1408264 + 894 WP_003239098.1 N-acetylmuramoyl-L-alanine amidase -
DKG76_RS21900 1408301..1408438 - 138 WP_119913750.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
DKG76_RS07220 1408523..1408693 - 171 WP_003239095.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
DKG76_RS07225 1408693..1409439 - 747 WP_003239094.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
DKG76_RS07230 1409549..1410550 - 1002 WP_003239093.1 inorganic phosphate transporter -
DKG76_RS07235 1410563..1411180 - 618 WP_003218470.1 DUF47 domain-containing protein -
DKG76_RS07240 1411456..1412772 - 1317 WP_003239092.1 serine/threonine exchanger -
DKG76_RS07245 1413158..1414108 + 951 WP_003239090.1 ring-cleaving dioxygenase -
DKG76_RS21905 1414209..1414349 + 141 Protein_1354 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29084.57 Da        Isoelectric Point: 4.6191

>T105689 WP_003239094.1 NZ_CP029465:c1409439-1408693 [Bacillus inaquosorum]
MLLFFQIMVWCVMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKMVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T105689 NZ_CP029465:c1409439-1408693 [Bacillus inaquosorum]
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCGTCATGGCCGGATTAGGCTTATACGTGTACGCCACGTGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACATGGTACTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCTCTTCCCTATTTACCCACTGGGAACGGTACCTCATTGTCGCTGTCAGTTTCGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAATTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATCCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCATATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCCGATAAAATGAATTTAACAGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGACGATCCGGCAGACGTGCAAACCCGGCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAATGGTTCTCATTCCTTTTACCATCGAGACACAGAGCTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACTGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6555.59 Da        Isoelectric Point: 10.8401

>AT105689 WP_003239095.1 NZ_CP029465:c1408693-1408523 [Bacillus inaquosorum]
MERAFQNGCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT105689 NZ_CP029465:c1408693-1408523 [Bacillus inaquosorum]
ATGGAACGCGCGTTTCAAAACGGATGCGAGCCCCGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTTGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTTAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2M8T4L2

Antitoxin

Source ID Structure
AlphaFold DB G4NV07

References