Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 220914..221386 Replicon chromosome
Accession NZ_CP029462
Organism Megasphaera stantonii strain AJH120

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DKB62_RS01000 Protein ID WP_107196109.1
Coordinates 220914..221111 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DKB62_RS01005 Protein ID WP_107196108.1
Coordinates 221108..221386 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKB62_RS00980 217413..218963 + 1551 WP_087477024.1 polysaccharide biosynthesis protein -
DKB62_RS00990 219825..220220 - 396 WP_157949714.1 HEPN domain-containing protein -
DKB62_RS00995 220213..220554 - 342 WP_107196110.1 nucleotidyltransferase domain-containing protein -
DKB62_RS01000 220914..221111 - 198 WP_107196109.1 type II toxin-antitoxin system YafQ family toxin Toxin
DKB62_RS01005 221108..221386 - 279 WP_107196108.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DKB62_RS01010 221678..222025 - 348 WP_107196107.1 type II secretion system GspH family protein -
DKB62_RS01015 222143..222469 - 327 WP_107196106.1 hypothetical protein -
DKB62_RS01020 222665..222886 + 222 WP_107196105.1 hypothetical protein -
DKB62_RS01025 222943..223134 - 192 WP_107196131.1 transposon-encoded TnpW family protein -
DKB62_RS01030 223178..223819 - 642 WP_107196104.1 hypothetical protein -
DKB62_RS12455 224372..224719 - 348 WP_157949713.1 hypothetical protein -
DKB62_RS01045 225259..225894 - 636 WP_107196101.1 flavodoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(W) - 219825..255809 35984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-65)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7592.99 Da        Isoelectric Point: 9.8374

>T105686 WP_107196109.1 NZ_CP029462:c221111-220914 [Megasphaera stantonii]
MTYELVTTAKFRKDIKLMKKRGKNLKLLQEVLDTLLEGKLLDAKYKDHALVGNYIGFRECHIQPD

Download         Length: 198 bp

>T105686 NZ_CP029462:c221111-220914 [Megasphaera stantonii]
ATGACGTATGAATTAGTCACGACTGCAAAATTCCGCAAAGATATCAAACTCATGAAGAAGCGCGGCAAAAATTTGAAGCT
GCTGCAGGAGGTTCTCGATACATTATTGGAAGGGAAGCTGTTGGATGCAAAATATAAAGACCATGCACTGGTAGGAAATT
ATATTGGCTTTCGCGAATGTCATATACAGCCGGATTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10148.70 Da        Isoelectric Point: 5.1369

>AT105686 WP_107196108.1 NZ_CP029462:c221386-221108 [Megasphaera stantonii]
MAKTATINIRIEPEIKADVEKLFSSFGITVSDAVNIFLRKSLMEGGLPFDVKQPRYNAETEAAMQEARNIAAGMVPAKRY
ANAKELFEDLGV

Download         Length: 279 bp

>AT105686 NZ_CP029462:c221386-221108 [Megasphaera stantonii]
ATGGCCAAAACAGCGACAATTAATATACGAATTGAGCCAGAAATTAAAGCCGATGTAGAAAAGCTATTTTCCAGCTTTGG
GATTACCGTCAGCGACGCCGTAAATATCTTTTTGCGCAAATCGTTGATGGAAGGCGGGCTGCCCTTTGACGTGAAACAGC
CGCGGTATAATGCGGAAACCGAAGCGGCTATGCAGGAAGCTAGGAACATTGCGGCAGGAATGGTTCCGGCAAAGCGGTAT
GCGAATGCGAAAGAATTATTTGAGGACTTGGGCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References