Detailed information of TA system TA105683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2283842..2284820
• Replicon: chromosome
• Accession: NZ_CP029454
• Organism: Bacillus cereus strain FORC087

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: FORC087_RS11915
• Protein ID: WP_000624979.1
• Coordinates: 2283842..2284579 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: FORC087_RS11920
• Protein ID: WP_000237818.1
• Coordinates: 2284692..2284820 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC087_RS11890	2279458..2279865	+	408	WP_000063587.1	VOC family protein	-
FORC087_RS11895	2279887..2280267	+	381	WP_000497670.1	methyltransferase	-
FORC087_RS11900	2280425..2282110	-	1686	WP_139894451.1	alpha-keto acid decarboxylase family protein	-
FORC087_RS11905	2282218..2282700	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
FORC087_RS11910	2282867..2283604	+	738	WP_139894452.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
FORC087_RS11915	2283842..2284579	+	738	WP_000624979.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
FORC087_RS11920	2284692..2284820	+	129	WP_000237818.1	hypothetical protein	Antitoxin
FORC087_RS11925	2284893..2285069	+	177	WP_000852627.1	stage II sporulation protein SB	-
FORC087_RS11930	2285089..2285478	-	390	WP_000713864.1	YxeA family protein	-
FORC087_RS11935	2285690..2287159	+	1470	WP_139894453.1	beta-Ala-His dipeptidase	-
FORC087_RS11940	2287404..2288213	+	810	WP_000664542.1	C39 family peptidase	-
FORC087_RS11945	2288239..2288841	+	603	WP_000517260.1	hypothetical protein	-
FORC087_RS11950	2289082..2289333	-	252	WP_000827560.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28311.04 Da
• Isoelectric Point: 8.2998

>T105683 WP_000624979.1 NZ_CP029454:2283842-2284579 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHMEQLNEQKAVQVENVGVIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T105683 NZ_CP029454:2283842-2284579 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTAGATATTGCATTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATGGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGGTTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT105683 WP_000237818.1 NZ_CP029454:2284692-2284820 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT105683 NZ_CP029454:2284692-2284820 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Antitoxin

• AlphaFold DB: W8YZL5