Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4884621..4885252 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P6GW52
Locus tag DKC05_RS25170 Protein ID WP_047730458.1
Coordinates 4884854..4885252 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SVC2
Locus tag DKC05_RS25165 Protein ID WP_047730457.1
Coordinates 4884621..4884854 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS25140 4879773..4881389 + 1617 WP_047730456.1 Tar ligand binding domain-containing protein -
DKC05_RS25145 4881427..4882299 + 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
DKC05_RS25150 4882299..4883348 + 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
DKC05_RS25155 4883451..4883840 + 390 WP_004934862.1 chemotaxis response regulator CheY -
DKC05_RS25160 4883851..4884495 + 645 WP_004934858.1 protein phosphatase CheZ -
DKC05_RS25165 4884621..4884854 + 234 WP_047730457.1 antitoxin Antitoxin
DKC05_RS25170 4884854..4885252 + 399 WP_047730458.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC05_RS25175 4885379..4886530 + 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
DKC05_RS25180 4886523..4888601 + 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
DKC05_RS25185 4888601..4889005 + 405 WP_047730460.1 flagellar protein FlhE -
DKC05_RS25190 4889334..4890149 + 816 WP_047730461.1 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14960.14 Da        Isoelectric Point: 7.4664

>T105674 WP_047730458.1 NZ_CP029449:4884854-4885252 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEVFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T105674 NZ_CP029449:4884854-4885252 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGTATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8841.85 Da        Isoelectric Point: 4.7815

>AT105674 WP_047730457.1 NZ_CP029449:4884621-4884854 [Serratia marcescens]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT105674 NZ_CP029449:4884621-4884854 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GW52

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SVC2

References