Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4120464..4121026 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DKC05_RS21565 Protein ID WP_047730131.1
Coordinates 4120670..4121026 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag DKC05_RS21560 Protein ID WP_004936539.1
Coordinates 4120464..4120673 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS21540 4116618..4116944 + 327 WP_004936551.1 phage holin, lambda family -
DKC05_RS21545 4116934..4117335 + 402 WP_038881240.1 M15 family metallopeptidase -
DKC05_RS21550 4117332..4117712 + 381 WP_047730130.1 DUF2570 family protein -
DKC05_RS28615 4117693..4117866 + 174 WP_038881246.1 hypothetical protein -
DKC05_RS21555 4118082..4120361 + 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
DKC05_RS21560 4120464..4120673 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DKC05_RS21565 4120670..4121026 + 357 WP_047730131.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DKC05_RS21570 4121038..4121976 - 939 WP_047730132.1 homocysteine S-methyltransferase -
DKC05_RS21575 4121966..4123375 - 1410 WP_047730133.1 S-methylmethionine permease -
DKC05_RS21580 4123553..4124392 + 840 WP_047730134.1 ChaN family lipoprotein -
DKC05_RS21585 4124495..4125292 + 798 WP_038881261.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13161.95 Da        Isoelectric Point: 4.9139

>T105673 WP_047730131.1 NZ_CP029449:4120670-4121026 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Download         Length: 357 bp

>T105673 NZ_CP029449:4120670-4121026 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT105673 WP_004936539.1 NZ_CP029449:4120464-4120673 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT105673 NZ_CP029449:4120464-4120673 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References