Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3635522..3636191 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name cptA Uniprot ID A0A5P6GZ53
Locus tag DKC05_RS19275 Protein ID WP_047729923.1
Coordinates 3635769..3636191 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag DKC05_RS19270 Protein ID WP_019455657.1
Coordinates 3635522..3635788 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS19245 3631097..3632023 + 927 WP_047729921.1 ribokinase -
DKC05_RS19250 3632056..3632664 - 609 WP_025304127.1 HD domain-containing protein -
DKC05_RS19255 3632848..3633522 + 675 WP_038871224.1 hemolysin III family protein -
DKC05_RS19260 3633673..3634170 + 498 WP_038871226.1 DUF2165 domain-containing protein -
DKC05_RS19265 3634209..3635201 - 993 WP_047729922.1 tRNA-modifying protein YgfZ -
DKC05_RS19270 3635522..3635788 + 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
DKC05_RS19275 3635769..3636191 + 423 WP_047729923.1 protein YgfX Toxin
DKC05_RS19280 3636191..3636886 + 696 WP_047729924.1 two-component system response regulator CreB -
DKC05_RS19285 3636883..3638301 + 1419 WP_047729925.1 two-component system sensor histidine kinase CreC -
DKC05_RS19290 3638382..3639746 + 1365 WP_047729926.1 cell envelope integrity protein CreD -
DKC05_RS19295 3639783..3640301 - 519 WP_038871234.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16500.57 Da        Isoelectric Point: 10.8114

>T105670 WP_047729923.1 NZ_CP029449:3635769-3636191 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPVGDGEEA

Download         Length: 423 bp

>T105670 NZ_CP029449:3635769-3636191 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
TGGGTGACGGCGAGGAGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT105670 WP_019455657.1 NZ_CP029449:3635522-3635788 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT105670 NZ_CP029449:3635522-3635788 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GZ53

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References