Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2655438..2656039 | Replicon | chromosome |
Accession | NZ_CP029449 | ||
Organism | Serratia marcescens strain CAV1761 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | DKC05_RS14665 | Protein ID | WP_033636540.1 |
Coordinates | 2655659..2656039 (+) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A0G3SPC0 |
Locus tag | DKC05_RS14660 | Protein ID | WP_038875999.1 |
Coordinates | 2655438..2655659 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DKC05_RS14645 | 2650587..2651564 | + | 978 | WP_016929588.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
DKC05_RS28590 | 2651566..2651718 | - | 153 | WP_168166338.1 | hypothetical protein | - |
DKC05_RS14650 | 2651914..2653977 | + | 2064 | WP_047729571.1 | alpha-amylase | - |
DKC05_RS14655 | 2654113..2655363 | + | 1251 | WP_004933935.1 | valine--pyruvate transaminase | - |
DKC05_RS14660 | 2655438..2655659 | + | 222 | WP_038875999.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
DKC05_RS14665 | 2655659..2656039 | + | 381 | WP_033636540.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
DKC05_RS14670 | 2656050..2657708 | - | 1659 | WP_047729572.1 | putative transporter | - |
DKC05_RS14675 | 2657876..2658304 | - | 429 | WP_004933922.1 | heat shock chaperone IbpB | - |
DKC05_RS14680 | 2658405..2658818 | - | 414 | WP_004933919.1 | heat shock chaperone IbpA | - |
DKC05_RS14685 | 2659128..2659475 | + | 348 | WP_016929593.1 | YceK/YidQ family lipoprotein | - |
DKC05_RS14690 | 2659506..2660786 | - | 1281 | WP_047729573.1 | DUF3748 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14185.53 Da Isoelectric Point: 7.3170
>T105669 WP_033636540.1 NZ_CP029449:2655659-2656039 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL
Download Length: 381 bp
>T105669 NZ_CP029449:2655659-2656039 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8563.50 Da Isoelectric Point: 4.4791
>AT105669 WP_038875999.1 NZ_CP029449:2655438-2655659 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE
Download Length: 222 bp
>AT105669 NZ_CP029449:2655438-2655659 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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