Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2655438..2656039 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DKC05_RS14665 Protein ID WP_033636540.1
Coordinates 2655659..2656039 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SPC0
Locus tag DKC05_RS14660 Protein ID WP_038875999.1
Coordinates 2655438..2655659 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS14645 2650587..2651564 + 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -
DKC05_RS28590 2651566..2651718 - 153 WP_168166338.1 hypothetical protein -
DKC05_RS14650 2651914..2653977 + 2064 WP_047729571.1 alpha-amylase -
DKC05_RS14655 2654113..2655363 + 1251 WP_004933935.1 valine--pyruvate transaminase -
DKC05_RS14660 2655438..2655659 + 222 WP_038875999.1 ribbon-helix-helix domain-containing protein Antitoxin
DKC05_RS14665 2655659..2656039 + 381 WP_033636540.1 type II toxin-antitoxin system VapC family toxin Toxin
DKC05_RS14670 2656050..2657708 - 1659 WP_047729572.1 putative transporter -
DKC05_RS14675 2657876..2658304 - 429 WP_004933922.1 heat shock chaperone IbpB -
DKC05_RS14680 2658405..2658818 - 414 WP_004933919.1 heat shock chaperone IbpA -
DKC05_RS14685 2659128..2659475 + 348 WP_016929593.1 YceK/YidQ family lipoprotein -
DKC05_RS14690 2659506..2660786 - 1281 WP_047729573.1 DUF3748 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-102)

Antitoxin

(3-40)


Sequences


Toxin        


Download         Length: 127 a.a.        Molecular weight: 14185.53 Da        Isoelectric Point: 7.3170

>T105669 WP_033636540.1 NZ_CP029449:2655659-2656039 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T105669 NZ_CP029449:2655659-2656039 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8563.50 Da        Isoelectric Point: 4.4791

>AT105669 WP_038875999.1 NZ_CP029449:2655438-2655659 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT105669 NZ_CP029449:2655438-2655659 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SPC0

References