Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2613268..2613803 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag DKC05_RS14485 Protein ID WP_038875945.1
Coordinates 2613268..2613543 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A255NGR4
Locus tag DKC05_RS14490 Protein ID WP_047729547.1
Coordinates 2613543..2613803 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS14465 2609086..2610078 - 993 WP_047729540.1 acyltransferase -
DKC05_RS14470 2610296..2611543 + 1248 WP_038875940.1 MFS transporter -
DKC05_RS14475 2611597..2612223 - 627 WP_047729542.1 LysE family translocator -
DKC05_RS14480 2612345..2613256 + 912 WP_047729544.1 LysR family transcriptional regulator -
DKC05_RS14485 2613268..2613543 - 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DKC05_RS14490 2613543..2613803 - 261 WP_047729547.1 ribbon-helix-helix domain-containing protein Antitoxin
DKC05_RS14495 2613886..2615727 - 1842 WP_047729548.1 selenocysteine-specific translation elongation factor -
DKC05_RS14500 2615724..2617118 - 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
DKC05_RS14505 2617186..2617791 - 606 WP_047729552.1 glutathione S-transferase -
DKC05_RS14510 2617832..2618482 - 651 WP_047729554.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T105668 WP_038875945.1 NZ_CP029449:c2613543-2613268 [Serratia marcescens]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T105668 NZ_CP029449:c2613543-2613268 [Serratia marcescens]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9696.04 Da        Isoelectric Point: 4.5201

>AT105668 WP_047729547.1 NZ_CP029449:c2613803-2613543 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALVDVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT105668 NZ_CP029449:c2613803-2613543 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGTCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A255NGR4

References