Detailed information of TA system TA105667

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 2581032..2581798
• Replicon: chromosome
• Accession: NZ_CP029449
• Organism: Serratia marcescens strain CAV1761

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A1Q4NZ32
• Locus tag: DKC05_RS14315
• Protein ID: WP_047729506.1
• Coordinates: 2581032..2581400 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: DKC05_RS14320
• Protein ID: WP_071845327.1
• Coordinates: 2581463..2581798 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DKC05_RS14290	2576131..2577297	-	1167	WP_047729497.1	MFS transporter	-
DKC05_RS14295	2577472..2578227	-	756	WP_047729499.1	nucleotidyltransferase domain-containing protein	-
DKC05_RS14300	2578214..2578726	-	513	WP_047729501.1	DUF962 domain-containing protein	-
DKC05_RS14305	2578933..2579976	-	1044	WP_047729502.1	virulence RhuM family protein	-
DKC05_RS14310	2580066..2580899	-	834	WP_047729504.1	DUF4942 domain-containing protein	-
DKC05_RS14315	2581032..2581400	-	369	WP_047729506.1	TA system toxin CbtA family protein	Toxin
DKC05_RS14320	2581463..2581798	-	336	WP_071845327.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DKC05_RS14325	2581810..2582289	-	480	WP_047729511.1	DNA repair protein RadC	-
DKC05_RS14330	2582471..2583091	-	621	WP_047730810.1	hypothetical protein	-
DKC05_RS14335	2583119..2583673	-	555	WP_047729513.1	hypothetical protein	-
DKC05_RS14340	2583921..2584676	-	756	WP_047730811.1	50S ribosome-binding GTPase	-
DKC05_RS14345	2584885..2585691	-	807	WP_047729515.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13731.73 Da
• Isoelectric Point: 7.2753

>T105667 WP_047729506.1 NZ_CP029449:c2581400-2581032 [Serratia marcescens]
MQTLPVTPKRAAYGCPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDTVIHEHIDAGISLADALNFTVEKFGLVRIDRRGF
SYREQSPFITAIDILRARRATGLMTRLGYQTITSVIRGEKQA

Nucleotide

• Length: 369 bp

>T105667 NZ_CP029449:c2581400-2581032 [Serratia marcescens]
ATGCAGACCTTACCTGTCACCCCGAAACGGGCGGCCTACGGTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATTTGCTGGAGCAGCATTACGGCTTGGCGCTTAACGATACCGAGTTCAGTGATGACACCGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTAGAAAAGTTTGGCCTGGTTCGCATCGATCGCCGGGGGTTT
TCCTATAGGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGCGCCCGTCGGGCCACCGGCCTAATGACCCGGCT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGAAAAGCAAGCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12341.01 Da
• Isoelectric Point: 4.9764

>AT105667 WP_071845327.1 NZ_CP029449:c2581798-2581463 [Serratia marcescens]
MPSIIAPVWGLKRNVTPQFGARLVQEGGRLHFLADRADISGTFSDEQLRDVDNAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSQGYVYLAIYPTPQPTA

Nucleotide

• Length: 336 bp

>AT105667 NZ_CP029449:c2581798-2581463 [Serratia marcescens]
ATGCCATCAATCATTGCCCCTGTCTGGGGACTTAAACGTAACGTCACTCCGCAGTTTGGCGCCCGCCTGGTACAGGAAGG
CGGGCGACTGCACTTCCTGGCTGACCGTGCCGATATCAGCGGTACCTTCAGCGACGAGCAGCTGCGTGACGTAGATAACG
CCTTCCCGCAGTTCATCAACCACCTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGTGTCACG
CTGTATTGCAATGGCTTGACCTGCGAAGCCGACAGTCTGGGATCACAGGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAACCAACTGCATAA

Structures

Toxin

• AlphaFold DB: A0A1Q4NZ32