Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2200112..2200683 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3SNA4
Locus tag DKC05_RS12520 Protein ID WP_038879053.1
Coordinates 2200112..2200387 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag DKC05_RS12525 Protein ID WP_013811307.1
Coordinates 2200396..2200683 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS12500 2195545..2196069 - 525 WP_047729213.1 NAD(P)H-dependent oxidoreductase -
DKC05_RS12505 2196176..2197090 + 915 WP_047729215.1 LysR family transcriptional regulator -
DKC05_RS12510 2197335..2199473 + 2139 WP_047729217.1 anaerobic ribonucleoside-triphosphate reductase -
DKC05_RS12515 2199642..2200106 + 465 WP_033636852.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DKC05_RS12520 2200112..2200387 - 276 WP_038879053.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DKC05_RS12525 2200396..2200683 - 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DKC05_RS12530 2200789..2201844 - 1056 WP_047729220.1 permease -
DKC05_RS12535 2202072..2202800 + 729 WP_047729221.1 phosphonate metabolism transcriptional regulator PhnF -
DKC05_RS12540 2202801..2203244 + 444 WP_019453314.1 phosphonate C-P lyase system protein PhnG -
DKC05_RS12545 2203248..2203829 + 582 WP_047729223.1 phosphonate C-P lyase system protein PhnH -
DKC05_RS12550 2203829..2204914 + 1086 WP_033636846.1 carbon-phosphorus lyase complex subunit PhnI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.52 Da        Isoelectric Point: 9.5103

>T105665 WP_038879053.1 NZ_CP029449:c2200387-2200112 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T105665 NZ_CP029449:c2200387-2200112 [Serratia marcescens]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGTCTGCTGGATCATCCTGAGTTAGGTAAGCCTTGGTATG
GGAAGGCACGTAAGTTGCTAATTAACAAGGCCTCCCTGTTGCTGGTGTATATCATCGTCGATGATGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGTGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT105665 WP_013811307.1 NZ_CP029449:c2200683-2200396 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT105665 NZ_CP029449:c2200683-2200396 [Serratia marcescens]
ATGGAAAGTCGCATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCGGAAGCTAAAGGAACGAC
ATTGAGTGAAGCCTGCCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCCGCGGAGGAGCACGAAAATTGGTTGA
AAGATAAGGTGGATGCAGCTTTTTCCCGTCTGCATGAGGGTAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATTAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3SNA4

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References